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Showing 1–5 of 5 results
Advanced filters: Author: Riccardo Dainese Clear advanced filters

  • Non-coding variants can regulate transcription factor binding and gene expression at variable chromatin modules. Here, the authors show that a germline variant induces transcription factor nucleation through chromatin compaction leading to AXIN2 up-regulation and is associated to better prognosis in chronic lymphocytic leukaemia.

    • Gerard Llimos
    • Vincent Gardeux
    • Bart Deplancke
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Live-seq, a single-cell transcriptome profiling approach that preserves cell viability during RNA extraction using fluidic force microscopy, can address a range of biological questions by transforming scRNA-seq from an end-point to a temporal analysis approach.

    • Wanze Chen
    • Orane Guillaume-Gentil
    • Bart Deplancke
    ResearchOpen Access
    Nature
    Volume: 608, P: 733-740

  • Although Krüppel-associated box zinc finger proteins (KZFPs) were found to mostly repress transposable elements, recent studies found that KFZPs also play other roles in cells. Here, the authors provide evidence that the KZFP ZFP30 promotes adipogenesis by targeting and activating a retrotransposon-derived Pparg2 enhancer in cooperation with co-regulator KRAB-associated protein 1 (KAP1).

    • Wanze Chen
    • Petra C. Schwalie
    • Bart Deplancke
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16