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Showing 1–3 of 3 results
Advanced filters: Author: Richa Bajpai Clear advanced filters

  • Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity.

    • Richa Bajpai
    • Aditi Sharma
    • Mala Shanmugam
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • p14ARF drives NPM1 phase separation and forms meso-scale assemblies that limit NPM1 dynamics. Here the authors show that p14ARF hydrophobic residues enhance NPM1 phase separation, promote p14ARF nucleolar partitioning, nucleolar NPM1 immobilization, and reduce cell viability.

    • Eric Gibbs
    • Qi Miao
    • Richard Kriwacki
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, their links with tumor progression and evolution, and their potential as therapeutic targets.

    • Yanling Liu
    • Jonathon Klein
    • Xiaotu Ma
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18