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Showing 1–3 of 3 results
Advanced filters: Author: Richard E. Gillilan Clear advanced filters

  • Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. Here, the authors identify a bipartite Nuclear Localization Signal in the NF-κB p50/p65 heterodimer that is recognized with high affinity by importin α3.

    • Tyler J. Florio
    • Ravi K. Lokareddy
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.

    • Rajeshwer S. Sankhala
    • Ravi K. Lokareddy
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Biological questions that involve determining changes in protein structure that occur in solution may be answered using small-angle X-ray scattering. This protocol describes the sample preparation as well as the data collection and analysis.

    • Soren Skou
    • Richard E Gillilan
    • Nozomi Ando
    Protocols
    Nature Protocols
    Volume: 9, P: 1727-1739