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Showing 1–8 of 8 results
Advanced filters: Author: Richard J Maraia Clear advanced filters

  • Bone maintenance in health and disease depends on bone-resorbing osteoclasts. Whitlock et al. demonstrate that an RNA chaperon -La protein- lives a second life as a key regulator of osteoclast size and function, suggesting a new therapeutic target.

    • Jarred M. Whitlock
    • Evgenia Leikina
    • Leonid V. Chernomordik
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • RNA polymerase III (Pol III) employs termination-associated reinitiation-recycling to express high amounts of tRNAs, which involves the essential C11 subunit. Here the authors determine the functions of various C11 domains, finding that the N-terminal domain (NTD) stimulates termination, reinitiation-recycling requires an NTD-linker, and the C-terminal domain stimulates RNA 3′-cleavage.

    • Saurabh Mishra
    • Shaina H. Hasan
    • Richard J. Maraia
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Postsynthetic modifications are widespread in genetic regulation. Trm9-mediated modification of the anticodon wobble base of specific tRNAs modulates expression of DNA damage response mRNAs in which cognate codons are unusually overrepresented. Thus, modification-dependent tRNA decoding activity is keyed to codon use in a genetic program.

    • Richard J Maraia
    • Nathan H Blewett
    • Mark A Bayfield
    News & Views
    Nature Chemical Biology
    Volume: 4, P: 162-164

  • Three structures of the enzyme RNA polymerase III, which is responsible for the synthesis of abundant short RNAs, reveal the specializations that make it an adept terminator and reinitiator of transcription. See Article p.231

    • Richard J. Maraia
    • Keshab Rijal
    News & Views
    Nature
    Volume: 528, P: 204-205

  • The La protein binds precursor tRNAs at their 3′ ends, thus facilitating maturation. Crystal structures indicate that the most obvious RNA-recognition motif does not bind this pre-tRNA tail, but studies now indicate that La has two distinct binding sites for the pre-mRNA. Recognition through these two sites may help distinguish precursor from product, an idea supported by biochemical studies here.

    • Mark A Bayfield
    • Richard J Maraia
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 430-437