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Showing 1–28 of 28 results
Advanced filters: Author: Richard J. Youle Clear advanced filters

  • The PINK1 ubiquitin kinase is shown to recruit the two autophagy receptors NDP52 and OPTN to mitochondria to activate mitophagy directly, independently of the ubiquitin ligase parkin; once recruited to mitochondria, NDP52 and OPTN recruit autophagy initiation components, and parkin may amplify the phospho-ubiquitin signal generated by PINK1, resulting in robust autophagy induction.

    • Michael Lazarou
    • Danielle A. Sliter
    • Richard J. Youle
    Research
    Nature
    Volume: 524, P: 309-314

  • Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent sequestration of mitochondria in Rab5-positive early endosomes.

    • Babette C. Hammerling
    • Rita H. Najor
    • Åsa B. Gustafsson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Competition is fierce in the microbial world, making evolutionary training and fitness essential for a microorganism to survive and thrive. To honour this spirit, in this Essay an expert panel has selected seven special events to make up the inaugural Microbial Olympics.

    • Merry Youle
    • Forest Rohwer
    • S. Craig Cary
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 10, P: 583-588

  • Mitophagy is the elimination of damaged mitochondria by the autophagosome regulated by the ubiquitin ligase, parkin and the kinase PINK1; a genome-wide RNAi screen with high-content microscopy has identified new genes that have an upstream role in parkin translocation to the mitochondria.

    • Samuel A. Hasson
    • Lesley A. Kane
    • Richard J. Youle
    Research
    Nature
    Volume: 504, P: 291-295

  • Hsu et al. show that mitochondrial import blockage stress activates the ATP-dependent protease YME1L1, which degrades mitochondrial presequence translocase TIM23 subunits to promote cell growth.

    • Meng-Chieh Hsu
    • Hiroki Kinefuchi
    • Richard J. Youle
    Research
    Nature Cell Biology
    Volume: 27, P: 309-321

  • Mitophagy is the selective elimination of mitochondria through autophagy. Recent studies have uncovered the molecular mechanisms mediating mitophagy in yeast and mammalian cells and have revealed that the dysregulation of one of these mechanisms — the PINK1–parkin-mediated signalling pathway — may contribute to Parkinson's disease.

    • Richard J. Youle
    • Derek P. Narendra
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 9-14

  • Narendra and Youle review the current understanding of the role of PINK1–Parkin in the quality control of mitophagy, highlighting the underlying mechanisms and physiological relevance of the pathway, as well as its role in neuroprotection.

    • Derek P. Narendra
    • Richard J. Youle
    Reviews
    Nature Cell Biology
    Volume: 26, P: 1639-1651

  • The extent to which damaged and undamaged structures can be segregated within the mitochondrial network during mitophagy is unclear. Abeliovich et al. show that mitochondrial matrix proteins undergo mitophagic degradation at different rates, and that this depends on regulators of mitochondrial dynamics.

    • Hagai Abeliovich
    • Mostafa Zarei
    • Joern Dengjel
    Research
    Nature Communications
    Volume: 4, P: 1-11

  • Studies of rare hereditary disorders are intended to find treatments, but they can also bring other discoveries. One such study links the dysfunction of a protein to that of the cell's energy producers, the mitochondria.

    • Derek P. Narendra
    • Richard J. Youle
    News & Views
    Nature
    Volume: 483, P: 418-419

  • The mitochondrial network fragments during mitosis to allow proper segregation of the organelles between daughter cells. Two mitotic kinases, the cyclin B–CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission.

    • Koji Yamano
    • Richard J. Youle
    News & Views
    Nature Cell Biology
    Volume: 13, P: 1026-1027

  • Under steady-state conditions, the E3 ubiquitin ligase Parkin is localized to the cytosol in an autoinhibited state. Two recent studies describe the mechanism of Parkin activation by phosphorylation via structural rearrangement of the Ubl and RING2 domains, explaining how the RING2 domain is released from the core of Parkin to allow for ubiquitination of its substrates.

    • François Le Guerroué
    • Richard J. Youle
    News & Views
    Nature Structural & Molecular Biology
    Volume: 25, P: 644-646

  • BCL-2 family proteins have either pro- or anti-apoptotic activities that are crucial for the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. Recent advances suggest that interactions between BCL-2 family proteins affect their localization and conformation and regulate their bioactivity.

    • Richard J. Youle
    • Andreas Strasser
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 47-59

  • MCL-1 is an anti-apoptotic BCL-2 family member and is frequently upregulated in cancer, but the mechanism by which it promotes cell survival has been elusive. Opferman and colleagues provide insight into this process by showing that MCL-1 exists in different forms with discrete localizations and functions. MCL-1 variants targeted to the outer mitochondrial membrane antagonize BAX and BAK activation, whereas an N-terminally truncated isoform localizes to the mitochondrial matrix and regulates mitochondrial metabolism.

    • Rhonda M. Perciavalle
    • Daniel P. Stewart
    • Joseph T. Opferman
    Research
    Nature Cell Biology
    Volume: 14, P: 575-583

  • Selective autophagy engages several cargo receptors that target specific, potentially toxic, content (damaged organelles, protein aggregates, pathogens) for lysosomal degradation. Understanding of the mechanisms governing this process in mammals has expanded in recent years, opening the prospects for enhancing selective autophagy to boost cellular quality control capabilities.

    • Jose Norberto S. Vargas
    • Maho Hamasaki
    • Tamotsu Yoshimori
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 167-185