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Showing 1–4 of 4 results
Advanced filters: Author: Richard P. Ramonell Clear advanced filters

  • Single-cell B cell repertoire analysis identifies the expansion of a naive-derived population of antibody-secreting cells contributing to de novo autoreactivity in patients with severe COVID-19 and those with post-COVID symptoms.

    • Matthew C. Woodruff
    • Richard P. Ramonell
    • Ignacio Sanz
    ResearchOpen Access
    Nature
    Volume: 611, P: 139-147

  • Sanz and colleagues examine B cell subsets in a cohort of patients with COVID-19. Severely ill patients have higher frequencies of activated extrafollicular T-bet+ B cells that form antibody-secreting cells, the majority of which express germline sequences and are reminiscent of antibody responses observed in patients with systemic lupus erythematosus during flares.

    • Matthew C. Woodruff
    • Richard P. Ramonell
    • Ignacio Sanz
    Research
    Nature Immunology
    Volume: 21, P: 1506-1516

  • Post-acute sequelae of COVID-19 (PASC) has heterogenous presentation and complex etiology. Here the authors profile peripheral blood of patients with PASC and analyze by machine-learning to identify immune and serology features that allow the stratification of PASC into inflammatory and non-inflammatory types for better diagnosis and therapy-planning.

    • Matthew C. Woodruff
    • Kevin S. Bonham
    • Ignacio Sanz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13