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Showing 1–2 of 2 results
Advanced filters: Author: Richard Simmerman Clear advanced filters

  • In this work the authors investigate the structure-sequence dependance. The ability to design and characterize proteins at interfaces between three common folds suggests that fold switching is an intrinsic feature of protein folding language and likely important in the evolution of protein structure and function.

    • Biao Ruan
    • Yanan He
    • Philip N. Bryan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engineered to cleave this region degraded RAS in vitro and in cells with a promise of adaptability for other target proteins too.

    • Yingwei Chen
    • Eric A. Toth
    • Philip N. Bryan
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13