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Showing 1–7 of 7 results
Advanced filters: Author: Richiro Ushimaru Clear advanced filters

  • The mechanism by which sulfur is incorporated into the furanose ring in albomycins—a group of natural nucleoside antibiotics—remains unclear. Now, this work explains how twitch radical S-adenosyl-l-methionine enzyme AbmM catalyses sulfur-for-oxygen replacement in the biosynthesis of albomycin δ2.

    • Richiro Ushimaru
    • Ziyang Zheng
    • Hung-wen Liu
    Research
    Nature Catalysis
    Volume: 8, P: 760-770

  • Tandem cycloaddition reactions have significant applications in organic synthetic chemistry. Now, two enzymes are shown to catalyse tandem hetero-Diels–Alder reactions with a synergistic interplay between a calcium cofactor and N-glycan post-translational modifications during the biosynthesis of bistropolone-sesquiterpene secondary metabolites.

    • Richiro Ushimaru
    • Ikuro Abe
    News & Views
    Nature Chemistry
    Volume: 15, P: 1056-1057

  • The Lycopodium alkaloids represent a valuable source of neuroactive compounds. The biosynthesis of these specialized metabolites is now shown to involve three α-carbonic anhydrase-like enzymes that are responsible for constructing the key carbon–carbon bonds within their distinctive polycyclic alkaloid structures.

    • Richiro Ushimaru
    • Ikuro Abe
    News & Views
    Nature Plants
    Volume: 9, P: 1946-1947

  • Recently, the pyridoxal-5′-phosphate-dependent enzyme SbzP was reported to catalyse a [3+2]-annulation reaction yielding β-NAD-derived antibiotics. Now, cryo-electron microscopy structures of a stable homologue and computational simulations provide structural and mechanistic insights into this enzymatic reaction.

    • Takayoshi Awakawa
    • Takahiro Mori
    • Ikuro Abe
    ResearchOpen Access
    Nature Catalysis
    Volume: 7, P: 1099-1108

  • Many endoperoxide-containing natural products have been isolated, but the biosynthesis of the endoperoxides remains unclear. Here, the authors report the structural and functional analysis of the NvfI endoperoxidase that catalyzes the formation of fumigatonoid A in the biosynthesis of novofumigatonin, and show that it does not employ tyrosyl radical in the reaction.

    • Takahiro Mori
    • Rui Zhai
    • Ikuro Abe
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11