Nature Search

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

Linda Diehl
Annemieke Th. den Boer
Rene E. M. Toes
Research01 Jul 1999
Nature Medicine

Volume: 5, P: 774-779
C₃-symmetric peptide scaffolds are functional mimetics of trimeric CD40L

Sylvie Fournel
Sébastien Wieckowski
Gilles Guichard
Research06 Nov 2005
Nature Chemical Biology

Volume: 1, P: 377-382
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

Stephen P. Schoenberger
Rene E. M. Toes
Cornelis J. M. Melief
Research04 Jun 1998
Nature

Volume: 393, P: 480-483
Characterization of single neurons reprogrammed by pancreatic cancer

A technique that combines retrograde axon tracing with single-cell transcriptomics is used to characterize neurons innervating pancreatic ductal adenocarcinoma and healthy pancreas, providing insight into the role of neural connections in cancer progression.

Vera Thiel
Simon Renders
Andreas Trumpp
ResearchOpen Access17 Feb 2025
Nature

Volume: 640, P: 1042-1051
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy

Immune checkpoint inhibitors have limited efficacy in tumors with lower mutational burden and non-permissive microenvironment. Here, the authors show that combining MEK inhibition with an agonist anti-CD40 immunostimulatory antibody improves antitumor treatment by inducing immunogenic changes in the tumor microenvironment.

Daniel Baumann
Tanja Hägele
Rienk Offringa
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-18
Frequent mutations in the 3′-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours

Jan Willem F Dierssen
Marjo van Puijenbroek
Hans Morreau
Research16 Apr 2008
European Journal of Human Genetics

Volume: 16, P: 1235-1239
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

Thorbald van Hall
Elisabeth Z Wolpert
Rienk Offringa
Research19 Mar 2006
Nature Medicine

Volume: 12, P: 417-424
The expanding role for small molecules in immuno-oncology

This Review provides an update on the application of small-molecule drugs in immuno-oncology, discussing current development of small molecules designed to stimulate the antitumour immune response directly and indirectly, and the rapidly increasing efforts towards the discovery of small molecules that target T cell checkpoints.

Rienk Offringa
Lisa Kötzner
Klaus Urbahns
Reviews18 Aug 2022
Nature Reviews Drug Discovery

Volume: 21, P: 821-840
Dual effect of Kras^D12 knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy

Niels Smakman
Liesbeth M Veenendaal
Onno Kranenburg
Research08 Aug 2005
Oncogene

Volume: 24, P: 8338-8342
Cancer immunotherapy: exploiting neoepitopes

The efficacy of cancer vaccines has long been hampered by insufficient definition of tumor-specific antigens. A recent study by Kreiter et al. published in Nature has provided a blueprint for a patient-tailored approach to develop individualized RNA vaccines.

Michael Platten
Rienk Offringa
Research Highlights02 Jun 2015
Cell Research

Volume: 25, P: 887-888
Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line

Philipp Schröter
Laura Hartmann
Stefan Rieken
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines

Laura Hartmann
Philipp Schröter
Stefan B. Eichmüller
ResearchOpen Access09 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients

Anand G Menon
Peter J K Kuppen
Cornelis J H van de Velde
Research30 Jun 2003
Cancer Gene Therapy

Volume: 10, P: 509-517

Search

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

C₃-symmetric peptide scaffolds are functional mimetics of trimeric CD40L

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

Characterization of single neurons reprogrammed by pancreatic cancer

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy

Frequent mutations in the 3′-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

The expanding role for small molecules in immuno-oncology

Dual effect of Kras^D12 knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy

Cancer immunotherapy: exploiting neoepitopes

Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line

Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines

Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients

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