DNA damage in renal proximal tubular epithelial cells may lead to impaired kidney function but the biological processes contributing to this functional decline are incompletely understood. Here, the authors show that DNA double-strand breaks in these renal epithelial cells alter the epigenetic landscape of myeloid cells in the kidney and peripheral blood, which in turn induces systemic metabolic changes and reinforces the metabolic vicious circle.
- Erina Sugita Nishimura
- Akihito Hishikawa
- Kaori Hayashi
