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Showing 1–13 of 13 results
Advanced filters: Author: Rinku Jain Clear advanced filters

  • Cisplatin forms intrastrand cross-links on DNA and is a widely used chemotherapy agent. Among human translesion DNA polymerases, Pol-η can bypass cisplatin adducts. The crystal structure of human Pol-η in complex with a DNA template with a cisplatin lesion is now presented. In addition to the larger active site, the structure reveals specific interactions with the adduct by residues that are not conserved in other translesion polymerases.

    • Ajay Ummat
    • Olga Rechkoblit
    • Aneel K Aggarwal
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 628-632

  • A unique arrangement of catalytic and regulatory subunits revealed by cryo-EM analysis of DNA polymerase δ holoenzyme in a template–primer complex suggests how interactions between the functional modules promote DNA synthesis and proofreading activities.

    • Rinku Jain
    • William J. Rice
    • Aneel K. Aggarwal
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 955-962

  • A crystal structure of the Zika virus NS3 RNA helicase reveals similarities to the RNA helicase from Dengue virus, with variability in loops typically involved in binding ATP and RNA, and aids in identification of potentially druggable hotspots.

    • Rinku Jain
    • Javier Coloma
    • Aneel K Aggarwal
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 752-754

  • PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays provide a mechanism for PAPP-A substrate binding and selectivity.

    • Russell A. Judge
    • Janani Sridar
    • Qi Hao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.

    • Qi Hao
    • Jin-Mi Heo
    • Carmela Sidrauski
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Ultraviolet radiation causes damage to DNA in skin cells, blocking DNA replication and causing mutations that can lead to cancer. One way in which the cell deals with such damage involves specialized DNA polymerases, such as Polη, that can bypass lesions. Here the crystal structure is presented of Pol? in complex with a thymine–thymine dimer and with undamaged DNA. The bulky thymine dimer is accommodated in an atypically large active site, and stabilized by interactions not found in other polymerases.

    • Timothy D. Silverstein
    • Robert E. Johnson
    • Aneel K. Aggarwal
    Research
    Nature
    Volume: 465, P: 1039-1043

  • PTPN2 (protein tyrosine phosphatase non-receptor type 2) and PTPN1 are attractive immuno-oncology targets, however, targeting PTPN2/N1 poses significant challenges. Here, the authors report the development of potent PTPN2/N1 heterobifunctional degraders and reveal biochemical and structural insights into the formation of ternary structures with cereblon E3 ligase by X-ray diffraction, cryo-EM and MD simulations.

    • Qi Hao
    • Manoj K. Rathinaswamy
    • Michael E. Kort
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-16