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Showing 1–14 of 14 results
Advanced filters: Author: Rob Middleton Clear advanced filters

  • A new ultraluminous X-ray source has been discovered in M 31, whose variability and associated bright, compact radio emission identify it as a stellar-mass black hole accreting close to the Eddington limit.

    • Matthew J. Middleton
    • James C. A. Miller-Jones
    • Keith Grainge
    Research
    Nature
    Volume: 493, P: 187-190

  • Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor recruitment near affected splice junctions.

    • Justin J. -L. Wong
    • Dadi Gao
    • John E. J. Rasko
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • A set of three papers in Nature reports a new proteomics resource from the UK Biobank and initial analysis of common and rare genetic variant associations with plasma protein levels.

    • Ryan S. Dhindsa
    • Oliver S. Burren
    • Slavé Petrovski
    ResearchOpen Access
    Nature
    Volume: 622, P: 339-347

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Genome-wide association analysis of an improved telomere length score, calculated from quantitative PCR and whole-genome sequencing measurements in 462,666 individuals in the UK Biobank, identifies novel genes and variants underlying this trait.

    • Oliver S. Burren
    • Ryan S. Dhindsa
    • Slavé Petrovski
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1832-1840

  • Patient-derived xenografts are important tools for cancer drug development. Here, the authors develop models from 22 non-small cell lung cancer patients. They show genomic differences between models created from different spatial regions of tumours and a bottleneck on model establishment.

    • Robert E. Hynds
    • Ariana Huebner
    • Charles Swanton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • The relativistic jets associated with the black-hole X-ray binary system V404 Cygni change their orientation on time scales of minutes to hours, implying that the direction of the jets is being affected by the dynamics of the surrounding accretion flow that powers them.

    • James C. A. Miller-Jones
    • Alexandra J. Tetarenko
    • Valeriu Tudose
    Research
    Nature
    Volume: 569, P: 374-377

  • Yuen et al. developed a cloud-based database with 5,205 whole genomes from families with autism spectrum disorder (ASD). They identified 18 new candidate ASD-risk genes and approximately 100 risk genes and copy-number loci, which account for 11% of the cases. They also found that individuals bearing mutations in ASD-risk genes had lower adaptive ability.

    • Ryan K C Yuen
    • Daniele Merico
    • Stephen W Scherer
    Research
    Nature Neuroscience
    Volume: 20, P: 602-611

  • Geroscience is becoming a major hope for preventing age-related diseases and loss of function by targeting biological mechanisms of aging. This article reports a discussion of a research Task Force on the challenges posed by the clinical research in Geroscience so that future gerotherapeutic clinical trials can be conducted successfully.

    • Yves Rolland
    • Felipe Sierra
    • Alex Zhavoronkov
    ReviewsOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

    • Malcolm G Dunlop
    • Sara E Dobbins
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 44, P: 770-776