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Showing 1–7 of 7 results
Advanced filters: Author: Robert A. Beagrie Clear advanced filters

  • Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may explain the ancient synteny of α -globin with Nprl3.

    • Alexandra E. Preston
    • Joe N. Frost
    • Hal Drakesmith
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and apply it to mouse erythroid differentiation in vivo, finding that enhancer-promoter interactions are formed gradually during differentiation, concomitant with progressive upregulation of gene activity.

    • A. Marieke Oudelaar
    • Robert A. Beagrie
    • Jim R. Hughes
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • A technique called genome architecture mapping (GAM) involves sequencing DNA from a large number of thin nuclear cryosections to develop a map of genome organization without the limitations of existing 3C-based methods.

    • Robert A. Beagrie
    • Antonio Scialdone
    • Ana Pombo
    Research
    Nature
    Volume: 543, P: 519-524

  • DNA is packaged in the cell as chromatin, which folds into organized domains. Mapping of chromatin contacts in single cells sheds light on the dynamic evolution of these domains between cell divisions. See Article p.61

    • Robert A. Beagrie
    • Ana Pombo
    News & Views
    Nature
    Volume: 547, P: 34-35

  • Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super-enhancer, and zeta-globin can be reactivated by acetylation.

    • Andrew J. King
    • Duantida Songdej
    • Christian Babbs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15