Effective synthetic anion receptors are challenging to design. Now, star-shaped macrocycles, with a cavity defined by multiple convergent amide NH and phenyl CH groups, have been synthesized in one pot from their monomeric building blocks. These macrocycles strongly bind a variety of anions, selectively transport chloride across cell membranes and restore the function of cystic fibrosis cells.
- Ruikai Cao
- Robert B. Rossdeutcher
- Bing Gong
