Several molecular pathways and cellular effector functions have been described for the pathology of rheumatoid arthritis, but fundamental questions remain about the basic organization of disease-driving immune responses. In this Review, Benson and colleagues describe how intact tissue imagingin vivohas facilitated studies of the dynamic nature of cellular immune responses, and how these findings can be translated to new therapeutics.
- Robert A. Benson
- Iain B. McInnes
- Paul Garside
