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Showing 1–13 of 13 results
Advanced filters: Author: Robert D. Bjornson Clear advanced filters

  • Post-drought rehydration triggers a preventive immune response in plants, revealing targets to enhance crop resilience by linking drought stress recovery with improved pathogen resistance.

    • Natanella Illouz-Eliaz
    • Jingting Yu
    • Joseph R. Ecker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

    • Richard M. Durbin
    • David Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 467, P: 1061-1073

  • Exome sequencing of 2,871 probands with congenital heart disease (CHD) provides new insights into the genetic architecture of these disorders. The results implicate new genes in CHD pathogenesis and highlight striking overlap between genes with damaging de novo mutations in individuals with CHD and autism.

    • Sheng Chih Jin
    • Jason Homsy
    • Martina Brueckner
    Research
    Nature Genetics
    Volume: 49, P: 1593-1601

  • Richard Lifton and colleagues report a genomic analysis of cutaneous T cell lymphoma (CTCL). Their results implicate several pathways in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response.

    • Jaehyuk Choi
    • Gerald Goh
    • Richard P Lifton
    Research
    Nature Genetics
    Volume: 47, P: 1011-1019

  • Repetitive sequences and chromatin accessibility can confound scoring of chromatin immunoprecipitation data generated by high–throughput sequencing. Using data sets they produce for human RNA polymerase II and the transcription factor STAT1, Rozowsky et al. compensate for these biases by correcting for 'mappability' and normalizing the data against an input–DNA control.

    • Joel Rozowsky
    • Ghia Euskirchen
    • Mark B Gerstein
    Research
    Nature Biotechnology
    Volume: 27, P: 66-75

  • The first week of life impacts health for all of life, but the mechanisms are little-understood. Here the authors extract multi-omic data from small volumes of blood to study the dynamic molecular changes during the first week of life, revealing a robust developmental trajectory common to different populations.

    • Amy H. Lee
    • Casey P. Shannon
    • Tobias R. Kollmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Exome sequencing of patients with congenital heart disease (CHD) and their unaffected parents reveals an excess of strong-effect, protein-altering de novo mutations in genes expressed in the developing heart, many of which regulate chromatin modification in key developmental genes; collectively, these mutations are predicted to account for approximately 10% of severe CHD cases.

    • Samir Zaidi
    • Murim Choi
    • Richard P. Lifton
    Research
    Nature
    Volume: 498, P: 220-223

  • Vincent Lynch and colleagues report the transcriptional landscapes of endometrial stromal cells from placental and marsupial mammals and identify 1,532 genes that are expressed in human and armadillo but not opossum. The authors suggest these genes were recruited into endometrial stromal cells during the evolution of pregnancy in placental mammals. Thirteen percent of these genes are located within 200 kb of a MER20 transposable element, and functional experiments show that MER20 elements regulate endometrial-specific gene expression response to progesterone and cAMP.

    • Vincent J Lynch
    • Robert D Leclerc
    • Günter P Wagner
    Research
    Nature Genetics
    Volume: 43, P: 1154-1159