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Showing 1–11 of 11 results
Advanced filters: Author: Robert Hänsel-Hertsch Clear advanced filters

  • Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and single cells, and apply it to assess changes in TF activity in SCLC tumours following chemotherapy.

    • Pascal Hunold
    • Giulia Pizzolato
    • Robert Hänsel-Hertsch
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Caspase 8 protein expression is largely absent in small cell lung cancer (SCLC) patients. Here, the authors generate a caspase 8 deletion SCLC mouse model and show that it promotes a neuronal progenitor-like cell state and pre-tumoral immunosuppression triggered by necroptosis that promotes metastasis.

    • Ariadne Androulidaki
    • Fanyu Liu
    • Silvia von Karstedt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

    • Vignesh Sakthivelu
    • Anna Schmitt
    • Filippo Beleggia
    ResearchOpen Access
    Nature
    Volume: 646, P: 1243-1253

  • DNA G-quadruplexes (G4s) are guanine-rich sequences that fold into four-stranded structures. Recent progress in the detection and mapping of genomic G4 structures has provided new insights into their functions in regulating transcription and genome stability, and has revealed their potential relevance for cancer therapy.

    • Robert Hänsel-Hertsch
    • Marco Di Antonio
    • Shankar Balasubramanian
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 279-284

  • Quantitative ChIP–seq analysis maps G-quadruplex (G4) DNA structures in breast cancer patient-derived tumor xenograft (PDTX) models. G4-based subtypes highlight additional tumor heterogeneity in the integrative cluster (IC) system.

    • Robert Hänsel-Hertsch
    • Angela Simeone
    • Shankar Balasubramanian
    Research
    Nature Genetics
    Volume: 52, P: 878-883

  • Biochemical and genome-wide analyses reveal that G4 structures sequester and inhibit the activity of DNMT1, thereby protecting CpG islands from methylation in human cells.

    • Shi-Qing Mao
    • Avazeh T. Ghanbarian
    • Shankar Balasubramanian
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 951-957

  • Double-strand DNA breaks capture (DSBCapture) identifies in situ DSBs via the ligation of an Illumina adaptor into the break site and shows no bias for chromatin state or base composition. A genome-wide DSB profile shows breaks occurring more frequently in euchromatin and transcriptionally active regions.

    • Stefanie V Lensing
    • Giovanni Marsico
    • Shankar Balasubramanian
    Research
    Nature Methods
    Volume: 13, P: 855-857

  • Shankar Balasubramanian and colleagues examine endogenous DNA G-quadruplex (G4) structures in the context of chromatin by using G4 antibody-based ChIP–seq. They find that G4 structures are enriched in nucleosome-depleted regions and the promoters and 5′ UTRs of highly transcribed genes, suggesting a relationship between chromatin state, transcriptional output and G4 status.

    • Robert Hänsel-Hertsch
    • Dario Beraldi
    • Shankar Balasubramanian
    Research
    Nature Genetics
    Volume: 48, P: 1267-1272