Nature Search

Martini 3: a general purpose force field for coarse-grained molecular dynamics

Martini 3.0 is an updated and reparametrized force field for coarse-grained molecular dynamics simulations with new bead types and an expanded ability to model molecular packing and interactions.

Paulo C. T. Souza
Riccardo Alessandri
Siewert J. Marrink
Research29 Mar 2021
Nature Methods

Volume: 18, P: 382-388
Accelerated growth increases the somatic epimutation rate in trees

Trees live centuries by slowing growth to protect their DNA. This study shows that faster growth increases the epimutation rate in European beech trees, supporting the idea that slow growth helps maintain genome stability.

Ming Zhou
Gerhard Schmied
Frank Johannes
ResearchOpen Access27 Oct 2025
Nature Communications

Volume: 16, P: 1-10
Tests of the helix dipole model for stabilization of α-helices

Kevin R. Shoemaker
Peter S. Kim
Robert L. Baldwin
Research09 Apr 1987
Nature

Volume: 326, P: 563-567
Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes

Effective synthetic anion receptors are challenging to design. Now, star-shaped macrocycles, with a cavity defined by multiple convergent amide NH and phenyl CH groups, have been synthesized in one pot from their monomeric building blocks. These macrocycles strongly bind a variety of anions, selectively transport chloride across cell membranes and restore the function of cystic fibrosis cells.

Ruikai Cao
Robert B. Rossdeutcher
Bing Gong
Research09 Oct 2023
Nature Chemistry

Volume: 15, P: 1559-1568
An extended X-ray low state from Hercules X-1

A. N. Parmar
W. Pietsch
P. Barr
Research10 Jan 1985
Nature

Volume: 313, P: 119-121
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achieving improved performance in mouse tumor models.

Patrick A. Baeuerle
Jian Ding
Robert Hofmeister
ResearchOpen Access07 May 2019
Nature Communications

Volume: 10, P: 1-12
In vivo chimeric antigen receptor (CAR)-T cell therapy

In vivo chimeric antigen receptor (CAR)-T cell engineering uses targeted delivery systems to generate CAR-T cells directly in patients, bypassing ex vivo manufacturing. This Review examines emerging viral and lipid nanoparticle platforms, early clinical proof of concept and potential applications beyond cancer.

Adrian Bot
Andrew Scharenberg
Carl H. June
Reviews30 Sept 2025
Nature Reviews Drug Discovery

Volume: 25, P: 116-137
Diversity of cytosine methylation across the fungal tree of life

A phylogenetic analysis reveals the evolutionary history of 5mC methyltransferases in fungi and finds that fungi lack the canonical gene-body methylation seen in other taxa.

Adam J. Bewick
Brigitte T. Hofmeister
Robert J. Schmitz
Research18 Feb 2019
Nature Ecology & Evolution

Volume: 3, P: 479-490
Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo

Liang Zhou
Yu Zhang
Steven Grant
ResearchOpen Access14 Dec 2017
British Journal of Cancer

Volume: 118, P: 388-397
Generation of histocompatible tissues using nuclear transplantation

Robert P. Lanza
Ho Yun Chung
Anthony Atala
Research03 Jun 2002
Nature Biotechnology

Volume: 20, P: 689-696
BEAM or BUCYVP16-conditioning regimen for autologous stem-cell transplantation in non-Hodgkin’s lymphomas

Sara Singer
Nidhi Sharma
Yvonne A. Efebera
Research04 Feb 2019
Bone Marrow Transplantation

Volume: 54, P: 1553-1561
Bioresponsive materials

Bioresponsive materials capable of responding to specific biological cues hold vast promise for developing next-generation precision medications. This Review highlights recent advances in the design of bioresponsive materials and provides insights into design rules as well as future perspectives.

Yue Lu
Alex A. Aimetti
Zhen Gu
Reviews25 Oct 2016
Nature Reviews Materials

Volume: 2, P: 1-17
Glycocalyx regulates the strength and kinetics of cancer cell adhesion revealed by biophysical models based on high resolution label-free optical data

Nicolett Kanyo
Kinga Dora Kovacs
Robert Horvath
ResearchOpen Access30 Dec 2020
Scientific Reports

Volume: 10, P: 1-20
Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials

Maria Gavriatopoulou
Ajai Chari
Meletios Athanasios Dimopoulos
ResearchOpen Access24 Feb 2020
Leukemia

Volume: 34, P: 2430-2440
Bone marrow-derived pancreatic stellate cells in rats

Gisela Sparmann
Marie-Luise Kruse
Jörg Emmrich
Research26 Jan 2010
Cell Research

Volume: 20, P: 288-298

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Martini 3: a general purpose force field for coarse-grained molecular dynamics

Accelerated growth increases the somatic epimutation rate in trees

Tests of the helix dipole model for stabilization of α-helices

Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes

An extended X-ray low state from Hercules X-1

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

In vivo chimeric antigen receptor (CAR)-T cell therapy

Diversity of cytosine methylation across the fungal tree of life

Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo

Generation of histocompatible tissues using nuclear transplantation

BEAM or BUCYVP16-conditioning regimen for autologous stem-cell transplantation in non-Hodgkin’s lymphomas

Bioresponsive materials

Glycocalyx regulates the strength and kinetics of cancer cell adhesion revealed by biophysical models based on high resolution label-free optical data

Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials

Bone marrow-derived pancreatic stellate cells in rats

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