Nature Search

HER2 in urothelial cancer: clinical speed outpacing diagnostic clarity

HER2-targeted antibody–drug conjugates are rapidly transforming the treatment landscape of urothelial carcinoma, with recent clinical trials positioning HER2-directed therapy as a new therapeutic pillar. Yet, this therapeutic acceleration has exposed a fundamental challenge: HER2-targeted drugs are advancing swiftly into early disease settings, but the field still lacks a coherent definition of what ‘HER2-positive’ means in urothelial cancer.

Emanuele Crupi
Filippo Pederzoli
Daniele Raggi
Comments & Opinion05 May 2026
Nature Reviews Urology

P: 1-3
Fertility, gonadal and sexual function in survivors of testicular cancer

R A Huddart
A Norman
D P Dearnaley
ResearchOpen Access05 Jul 2005
British Journal of Cancer

Volume: 93, P: 200-207
Evidence-based pragmatic guidelines for the follow-up of testicular cancer: optimising the detection of relapse

N J van As
D C Gilbert
R A Huddart
ReviewsOpen Access10 Jun 2008
British Journal of Cancer

Volume: 98, P: 1894-1902
Changing patterns of incidence in testicular germ cell tumours

Testicular germ cell tumours are the most common malignancy in young adult males. Recent data suggest that the predominant histological subtype appears to be shifting towards seminomas, which is mirrored in an increasing age at presentation. However, as nonseminomatous tumours present earlier, recent declines in its incidence might be more informative of overall trends.

Mausam Singhera
Robert Huddart
News & Views23 Apr 2013
Nature Reviews Urology

Volume: 10, P: 312-314
Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours

Elizabeth A. Rapley
Gillian P. Crockford
D. Timothy Bishop
Research01 Feb 2000
Nature Genetics

Volume: 24, P: 197-200
A genome-wide association study of testicular germ cell tumor

Michael Stratton and colleagues report a genome-wide association study for testicular germ cell tumor (TGCT) in a UK population, identifying three associated loci.

Elizabeth A Rapley
Clare Turnbull
Michael R Stratton
Research31 May 2009
Nature Genetics

Volume: 41, P: 807-810
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer

Clare Turnbull and colleagues identify three new risk loci for testicular germ cell cancer. The newly discovered risk variants reside near the telomere regulator genes TERT and ATF7IP and the sex determination gene DMRT1.

Clare Turnbull
Elizabeth A Rapley
Nazneen Rahman
Research13 Jun 2010
Nature Genetics

Volume: 42, P: 604-607
Multiple loci on 8q24 associated with prostate cancer susceptibility

Douglas Easton and colleagues report a comprehensive analysis of SNP associations to prostate cancer across the 8q24 region. They report 8 SNPs in 5 blocks independently associated to prostate cancer risk.

Ali Amin Al Olama
Zsofia Kote-Jarai
Douglas F Easton
Research20 Sept 2009
Nature Genetics

Volume: 41, P: 1058-1060
Retroperitoneal lymph-node dissection after chemotherapy for germ cell cancer in patients with elevated tumor markers

Alan Horwich
Robert Huddart
Comments & Opinion01 May 2006
Nature Clinical Practice Urology

Volume: 3, P: 250-251
Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours

Testicular germ cell tumour (TGCT) is the most common cancer in young men. Here, the authors sequence the whole exomes of 42 TGCTs, and characterize the mutational profile of this tumour type.

Kevin Litchfield
Brenda Summersgill
Clare Turnbull
ResearchOpen Access22 Jan 2015
Nature Communications

Volume: 6, P: 1-8
Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.

Kevin Litchfield
Max Levy
Clare Turnbull
ResearchOpen Access20 Dec 2016
Nature Communications

Volume: 7, P: 1-8
Identification of four new susceptibility loci for testicular germ cell tumour

This genome-wide association study identifies four novel risk loci for testicular germ cell tumour, and provides functional correlation between a disease-associated variant and gene expression in patient samples for one of the identified loci.

Kevin Litchfield
Amy Holroyd
Clare Turnbull
ResearchOpen Access27 Oct 2015
Nature Communications

Volume: 6, P: 1-8
Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database

Jakob Lauritsen
Nicolas Sauvé
Gedske Daugaard
ResearchOpen Access30 Sept 2023
British Journal of Cancer

Volume: 129, P: 1759-1765
HER2 and urothelial carcinoma: current understanding and future directions

In this Review the authors explore the emerging role of HER2 in urothelial carcinoma, highlighting its biological and clinical significance, the challenges of using HER2 as a biomarker, and the variability and complexity of HER2 assessment. Evidence supporting HER2-targeted therapies and future directions for research and clinical applications are also discussed.

Daniele Raggi
Emanuele Crupi
Matthew D. Galsky
Reviews15 Aug 2025
Nature Reviews Urology

Volume: 23, P: 110-132
Genomic landscape of platinum resistant and sensitive testicular cancers

Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-resistant disease.

Chey Loveday
Kevin Litchfield
Clare Turnbull
ResearchOpen Access04 May 2020
Nature Communications

Volume: 11, P: 1-12
Selective organ preservation with neo-adjuvant chemotherapy for the treatment of muscle invasive transitional cell carcinoma of the bladder

S Hafeez
A Horwich
R Huddart
ResearchOpen Access21 Apr 2015
British Journal of Cancer

Volume: 112, P: 1626-1635
The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 trial (CRUK/01/004)

Ananya Choudhury
Catharine M West
Nicholas James
ResearchOpen Access26 Jan 2017
British Journal of Cancer

Volume: 116, P: 649-657
Mapping of chromosome 3p deletions in human epithelial ovarian tumors

Hafida Lounis
Anne-Marie Mes-Masson
Patricia N Tonin
Research10 Oct 1998
Oncogene

Volume: 17, P: 2359-2365
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind Eeles and colleagues report meta-analysis of genome-wide association studies for prostate cancer and genotyping on the custom iCOGS array in 25,074 cases and 24,272 controls from 32 studies available in the PRACTICAL Consortium. They identify 23 new prostate cancer susceptibility loci, 20 of which are associated with both aggressive and non-aggressive disease.

Rosalind A Eeles
Ali Amin Al Olama
Douglas F Easton
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 385-391
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Rosalind Eeles and colleagues report a multistage genome-wide association study of prostate cancer, identifying seven new prostate cancer susceptibility loci.

Zsofia Kote-Jarai
Ali Amin Al Olama
Rosalind A Eeles
Research10 Jul 2011
Nature Genetics

Volume: 43, P: 785-791
Whole-genome sequencing analysis of clozapine-induced myocarditis

Ankita Narang
Paul Lacaze
Chad A. Bousman
Research23 Apr 2022
The Pharmacogenomics Journal

Volume: 22, P: 173-179
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor

Clare Turnbull and colleagues report discovery of 19 new susceptibility loci for testicular germ cell tumor (TGCT) and provide evidence for a network of physical interactions between TGCT risk variants and candidate causal genes. Their findings implicate widespread disruption of developmental transcriptional regulators in TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating step in oncogenesis.

Kevin Litchfield
Max Levy
Clare Turnbull
Research12 Jun 2017
Nature Genetics

Volume: 49, P: 1133-1140
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment

The genomic landscape of testicular germ cell tumour (TGCT) risk is dominated by inherited genetic factors, which are highly polygenic in nature. Here, the authors discuss results from genome-wide association studies that have identified risk loci associated with TGCT risk.KIT–KITLGsignalling is currently the major pathway that is implicated in TGCT formation.

Kevin Litchfield
Max Levy
Clare Turnbull
Reviews14 Jun 2016
Nature Reviews Urology

Volume: 13, P: 409-419
The present and future of serum diagnostic tests for testicular germ cell tumours

A need for improved serum diagnostic tests for testicular germ cell tumours (GCTs) exists owing to the unsatisfactory performance of currently used markers. In this Review, Murray and colleagues discuss the current serum diagnostic tests for testicular GCTs, including α-fetoprotein, human chorionic gonadotrophin and lactate dehydrogenase, and the future use of novel universal biomarkers such as microRNAs.

Matthew J. Murray
Robert A. Huddart
Nicholas Coleman
Reviews18 Oct 2016
Nature Reviews Urology

Volume: 13, P: 715-725
Multiple newly identified loci associated with prostate cancer susceptibility

Rosalind A Eeles
Zsofia Kote-Jarai
Douglas F Easton
Research10 Feb 2008
Nature Genetics

Volume: 40, P: 316-321
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14

Clare Turnbull and colleagues identify nine new susceptibility loci for testicular germ-cell tumor. The newly identified risk regions include variants near DAZL and PRDM14, genes known to be important for germ cell development.

Elise Ruark
Sheila Seal
Clare Turnbull
Research12 May 2013
Nature Genetics

Volume: 45, P: 686-689
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind Eeles and colleagues present a genome-wide association study for prostate cancer. They report seven loci newly associated with prostate cancer susceptibility.

Rosalind A Eeles
Zsofia Kote-Jarai
Douglas F Easton
Research20 Sept 2009
Nature Genetics

Volume: 41, P: 1116-1121
Survival from testicular cancer in England and Wales up to 2001

R A Huddart
Comments & OpinionOpen Access23 Sept 2008
British Journal of Cancer

Volume: 99, P: S83-S85
Amplification and overexpression of E2F3 in human bladder cancer

Andrew Feber
Jeremy Clark
Colin S Cooper
Research29 Dec 2003
Oncogene

Volume: 23, P: 1627-1630
Defining minimum genomic regions of imbalance involved in testicular germ cell tumors of adolescents and adults through genome wide microarray analysis of cDNA clones

Alan McIntyre
Brenda Summersgill
Janet Shipley
Research18 Oct 2004
Oncogene

Volume: 23, P: 9142-9147
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Erratum: Polygenic susceptibility to testicular cancer: implications for personalised health care

Kevin Litchfield
Jonathan S Mitchell
Clare Turnbull
Amendments and CorrectionsOpen Access26 May 2016
British Journal of Cancer

Volume: 114, P: e22
Polygenic susceptibility to testicular cancer: implications for personalised health care

Kevin Litchfield
Jonathan S Mitchell
Clare Turnbull
ResearchOpen Access13 Oct 2015
British Journal of Cancer

Volume: 113, P: 1512-1518
Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie?

Mareike K. Thompson
Philip Poortmans
Charlotte E. Coles
ReviewsOpen Access31 Jul 2018
British Journal of Cancer

Volume: 119, P: 389-407

Search

HER2 in urothelial cancer: clinical speed outpacing diagnostic clarity

Fertility, gonadal and sexual function in survivors of testicular cancer

Evidence-based pragmatic guidelines for the follow-up of testicular cancer: optimising the detection of relapse

Changing patterns of incidence in testicular germ cell tumours

Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours

A genome-wide association study of testicular germ cell tumor

Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer

Multiple loci on 8q24 associated with prostate cancer susceptibility

Retroperitoneal lymph-node dissection after chemotherapy for germ cell cancer in patients with elevated tumor markers

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours

Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

Identification of four new susceptibility loci for testicular germ cell tumour

Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database

HER2 and urothelial carcinoma: current understanding and future directions

Genomic landscape of platinum resistant and sensitive testicular cancers

Selective organ preservation with neo-adjuvant chemotherapy for the treatment of muscle invasive transitional cell carcinoma of the bladder

The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 trial (CRUK/01/004)

Mapping of chromosome 3p deletions in human epithelial ovarian tumors

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Whole-genome sequencing analysis of clozapine-induced myocarditis

Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor

The genomic landscape of testicular germ cell tumours: from susceptibility to treatment

The present and future of serum diagnostic tests for testicular germ cell tumours

Multiple newly identified loci associated with prostate cancer susceptibility

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Survival from testicular cancer in England and Wales up to 2001

Amplification and overexpression of E2F3 in human bladder cancer

Defining minimum genomic regions of imbalance involved in testicular germ cell tumors of adolescents and adults through genome wide microarray analysis of cDNA clones

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Erratum: Polygenic susceptibility to testicular cancer: implications for personalised health care

Polygenic susceptibility to testicular cancer: implications for personalised health care

Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie?

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