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Showing 1–5 of 5 results
Advanced filters: Author: Robert I. McGeachan Clear advanced filters

  • GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than rats, and a role for GABAB receptors in the anti-seizure profile of levetiracetam.

    • Max A. Wilson
    • Anna Sumera
    • Sam A. Booker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differences that associate with these protein markers.

    • Danni A. Gadd
    • Robert F. Hillary
    • Riccardo E. Marioni
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Here, Spires-Jones and colleagues review our current understanding of the mechanisms underlying synaptic degeneration in Alzheimer disease and highlight key questions that still need to be answered. They also discuss novel therapeutic approaches that target the synapse.

    • Makis Tzioras
    • Robert I. McGeachan
    • Tara L. Spires-Jones
    Reviews
    Nature Reviews Neurology
    Volume: 19, P: 19-38