Nature Search

Engineering kidney developmental trajectory using culture boundary conditions

Huang et al. show that 3D hydrogel embedding supports more organotypic kidney development in culture. Matrix stiffness and adhesion properties were found to regulate nephron formation, highlighting the intervention potential of physical boundary conditions.

Aria Zheyuan Huang
Louis S. Prahl
Alex J. Hughes
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Repression of RNA polymerase III transcription by the retinoblastoma protein

Robert J. White
Didier Trouche
Tony Kouzarides
Research04 Jul 1996
Nature

Volume: 382, P: 88-90
Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging

This study presents a framework combining theory and super-resolution imaging to uncover how chromatin-lamina interactions reorganize the genome across diverse microenvironments and regulate cell identity through molecular mechanisms.

Monika Dhankhar
Zixian Guo
Vivek B. Shenoy
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues

Tendon degeneration alters nanoscale chromatin organization in tenocytes and impacts their mechano-epigenetic memory.

Su-Jin Heo
Shreyasi Thakur
Melike Lakadamyali
Research22 Aug 2022
Nature Biomedical Engineering

Volume: 7, P: 177-191
Single-cell differences in matrix gene expression do not predict matrix deposition

Regenerative tissue engineering with mesenchymal stem cells is hampered by bulk methods of assessing differentiation status and a general assumption that expression of individual markers of stem cell differentiation correlate with functional capacity. Here the authors debunk this assumption by applying single-cell techniques to disassociate aggrecan mRNA abundance and matrix deposition.

Allison J. Cote
Claire M. McLeod
Robert L. Mauck
ResearchOpen Access03 Mar 2016
Nature Communications

Volume: 7, P: 1-13
Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration

Extracellular microinterfaces provide cells with migration tracks in vivo. Here, the authors introduce these microtracks into bicontinuous hydrogels to elicit rapid cell migration in 3-dimensional contexts.

Karen L. Xu
Nikolas Di Caprio
Jason A. Burdick
ResearchOpen Access29 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss

The loss of residual strains in the intervertebral disc alters the microenvironment and instigates aberrant tissue remodelling and the adoption of atypical cellular phenotypes, promoting disease progression.

Edward D. Bonnevie
Sarah E. Gullbrand
Robert L. Mauck
Research14 Oct 2019
Nature Biomedical Engineering

Volume: 3, P: 998-1008
Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments

Tools to investigate a wide range of 3D microenvironmental parameters are important for understanding and controlling cell fate. Here, the authors develop hydrogels with orthogonal biochemical gradients and use this screening system to identify microenvironments that induce mesenchymal stem cell chondrogenesis.

Sebastián L. Vega
Mi Y. Kwon
Jason A. Burdick
ResearchOpen Access09 Feb 2018
Nature Communications

Volume: 9, P: 1-10
Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels

The extracellular matrix surrounding cells plays a significant role in their behaviour. The spreading, mechanosensing and differentiation of mesenchymal stem cells are shown to be dependent on the early deposition and remodelling of local nascent proteins within degradable and viscoelastic hydrogels.

Claudia Loebel
Robert L. Mauck
Jason A. Burdick
Research18 Mar 2019
Nature Materials

Volume: 18, P: 883-891
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus

Designing load-bearing tissues that match the mechanical performance of native ones adds extra challenges to tissue engineering. Electrospinning of biodegradable polymer fibres into oriented sheets enables the production of laminate scaffolds; when seeded with mesenchymal stem cells and cultured for 10 weeks, these scaffolds replicate the mechanical properties of native annulus fibrosus.

Nandan L. Nerurkar
Brendon M. Baker
Robert L. Mauck
Research25 Oct 2009
Nature Materials

Volume: 8, P: 986-992
A single-cell transcriptional roadmap for cardiopharyngeal fate diversification

Wang et al. map early cardiopharyngeal development in the chordate model Ciona and show that FGF–MAPK signalling maintains multipotency and promotes pharyngeal muscle fate, whereas Tbx1/10-Dach specify second heart lineage identity.

Wei Wang
Xiang Niu
Lionel Christiaen
Research03 Jun 2019
Nature Cell Biology

Volume: 21, P: 674-686
High fidelity visualization of cell-to-cell variation and temporal dynamics in nascent extracellular matrix formation

Claire M. McLeod
Robert L. Mauck
ResearchOpen Access12 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Biomaterials in the repair of sports injuries

The optimal stimulation of tissue regeneration in bone, cartilage and spinal cord injuries involves a judicious selection of biomaterials with tailored chemical compositions, micro- and nanostructures, porosities and kinetic release properties for the delivery of relevant biologically active molecules.

Paul Ducheyne
Robert L. Mauck
Douglas H. Smith
Comments & Opinion24 Jul 2012
Nature Materials

Volume: 11, P: 652-654
Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair

Dense connective tissues do not easily heal, in part due to a low supply of reparative cells. Here, the authors develop a fibrous scaffold for meniscal repair that sequentially releases collagenase and a growth factor at the injury site, breaking down the extracellular matrix and recruiting endogenous cells.

Feini Qu
Julianne L. Holloway
Robert L. Mauck
ResearchOpen Access24 Nov 2017
Nature Communications

Volume: 8, P: 1-11
Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage

Tissue-engineered constructs with non-fibrous, proteoglycan-rich microdomains match the microstructural, micromechanical and mechanobiological properties of native fibrocartilaginous tissue.

Woojin M. Han
Su-Jin Heo
Dawn M. Elliott
Research04 Jan 2016
Nature Materials

Volume: 15, P: 477-484
N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

N-cadherin can alter how the stiffening extracellular microenvironment is interpreted by mesenchymal stem cells, leading to subsequent changes in downstream cell proliferation and differentiation.

Brian D. Cosgrove
Keeley L. Mui
Robert L. Mauck
Research15 Aug 2016
Nature Materials

Volume: 15, P: 1297-1306
Metabolic labeling of secreted matrix to investigate cell–material interactions in tissue engineering and mechanobiology

When cells are grown in or on a biomaterial, they continue to produce a natural extracellular matrix (ECM). This protocol describes the analysis of nascent ECM proteins using metabolic labeling, click chemistry, confocal microscopy and mass spectrometry.

Claudia Loebel
Aya M. Saleh
Jason A. Burdick
Protocols09 Feb 2022
Nature Protocols

Volume: 17, P: 618-648
Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission

Benjamin R. Freedman
Ashley B. Rodriguez
Louis J. Soslowsky
ResearchOpen Access18 Jul 2018
Scientific Reports

Volume: 8, P: 1-13
Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues

Feini Qu
Qing Li
Robert L. Mauck
ResearchOpen Access19 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Cell migration: implications for repair and regeneration in joint disease

Improved understanding of cell migration in the synovial joint, including the associated cellular and environmental factors, might reveal new therapeutic strategies for joint diseases such as rheumatoid arthritis and osteoarthritis and have important implications for tissue engineering of the joint.

Feini Qu
Farshid Guilak
Robert L. Mauck
Reviews07 Jan 2019
Nature Reviews Rheumatology

Volume: 15, P: 167-179
Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

Su-Jin Heo
Stephen D. Thorpe
Robert L. Mauck
ResearchOpen Access23 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Cell morphology and mechanosensing can be decoupled in fibrous microenvironments and identified using artificial neural networks

Edward D. Bonnevie
Beth G. Ashinsky
Robert L. Mauck
ResearchOpen Access15 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

Steven R. Caliari
Maryna Perepelyuk
Jason A. Burdick
ResearchOpen Access24 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Emerging therapies for cartilage regeneration in currently excluded ‘red knee’ populations

Anthony R. Martín
Jay M. Patel
Robert L. Mauck
ReviewsOpen Access30 May 2019
npj Regenerative Medicine

Volume: 4, P: 1-11

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