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Showing 1–21 of 21 results
Advanced filters: Author: Robert Lafyatis Clear advanced filters

  • Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.

    • Tracy Tabib
    • Mengqi Huang
    • Robert Lafyatis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Transforming growth factor-β (TGF-β), a key component in altered vascular and connective tissue homeostasis, is often linked with the pathogenesis of fibrotic diseases such as systemic sclerosis (SSc). In this Review, Lafyatis highlights the known mechanisms ofin situTGF-β activation and summarizes the evidence that place TGF-β at the centre of SSc pathogenesis.

    • Robert Lafyatis
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 706-719

  • Chromatin accessibility dynamics causally influence changes in gene expression levels, but these fluctuations may not be directly coupled over time. Here, authors develop computational causal framework HALO, examining epigenetic plasticity and gene regulation dynamics in single-cell multi-omic data.

    • Haiyi Mao
    • Minxue Jia
    • Panayiotis V. Benos
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The tumor microenvironment (TME) has an important role in Head and Neck Squamous Cell Carcinoma (HNSCC) progression. Here, using single-cell RNA sequencing and multiplexed imaging, the authors report the cellular complexity of the TME in patients with HNSCC, exploring inflammatory status, stromal heterogeneity and immune checkpoint receptor-ligand interactions.

    • Cornelius H. L. Kürten
    • Aditi Kulkarni
    • Robert L. Ferris
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Recent studies have highlighted a potentially important role for Wnts as profibrotic mediators, and implicated increased Wnt activity in systemic sclerosis and other fibrotic diseases. Strikingly, new data indicates that Wnts have a central role in the profibrotic activity of TGF-β.

    • Robert Lafyatis
    News & Views
    Nature Reviews Rheumatology
    Volume: 8, P: 441-442

  • Systemic sclerosis (SSc) is an autoimmune disease causing skin fibrosis and organ inflammation. Here the authors generate and analyze SSc skin single cell RNA sequencing data to propose contributions from both myofibroblasts and endothelial-to-mesenchymal -transitioning cells (EndoMT) to skin fibrosis, and to implicate the involvement of Hippo signaling pathways.

    • Feiyang Ma
    • Pei-Suen Tsou
    • Johann E. Gudjonsson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Assessing systemic sclerosis (SSc) disease activity is challenging, and improved outcome measures are needed. This Review describes clinical and biochemical outcome measures of distinct features of SSc, with an emphasis on the dermatological manifestations and interstitial lung disease, including insights into biomarkers gained from single-cell RNA sequencing.

    • Robert Lafyatis
    • Eleanor Valenzi
    Reviews
    Nature Reviews Rheumatology
    Volume: 18, P: 527-541

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559

  • Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in patients with head and neck squamous cell carcinoma and demonstrate that TLS with germinal centres are associated with better survival.

    • Ayana T. Ruffin
    • Anthony R. Cillo
    • Tullia C. Bruno
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.

    • Swati Bhattacharyya
    • Wenxia Wang
    • John Varga
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Exhausted T cells are associated with inefficient viral clearance, tumor immunity and response to immunotherapy. Here the authors show CD8+ T cells in the pancreatic islets have a LAG3-promoted ‘restrained’ phenotype resembling exhausted cells but maintain effector functions, and LAG3 expression limits pathology in the nonobese diabetic mouse model of type 1 diabetes.

    • Stephanie Grebinoski
    • Qianxia Zhang
    • Dario A. A. Vignali
    Research
    Nature Immunology
    Volume: 23, P: 868-877

  • Regulatory T cells obstruct effective anti-cancer immune responses. Vignali and colleagues demonstrate that IL-10 production and IL-35 production by tumor-infiltrating regulatory T cells mediate differential and non-redundant suppressive effects on tumor-reactive cytotoxic T cells.

    • Deepali V. Sawant
    • Hiroshi Yano
    • Dario A. A. Vignali
    Research
    Nature Immunology
    Volume: 20, P: 724-735

  • A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

    • Lisa Sikkema
    • Ciro Ramírez-Suástegui
    • Fabian J. Theis
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1563-1577

  • Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.

    • Linh T. Bui
    • Nichelle I. Winters
    • Laure Emmanuelle Zaragosi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The diagnosis, treatment and management of systemic sclerosis (SSc) remains challenging, owing to the complexity of this disease. In this Perspective, an international group of experts discuss the future of SSc research and how the advent of innovative technologies will advance research into and understanding of SSc.

    • David J. Abraham
    • Carol M. Black
    • Thomas Krieg
    Reviews
    Nature Reviews Rheumatology
    Volume: 21, P: 174-187

  • A number of core pathways and mechanisms of fibrosis, outlined in this Review, are shared across different tissues and might therefore present targets for general antifibrotic strategies. Organ-specific and disease-specific differences in fibrotic diseases could also provide insights for drug development efforts.

    • Jörg H. W. Distler
    • Andrea-Hermina Györfi
    • Robert Lafyatis
    Reviews
    Nature Reviews Rheumatology
    Volume: 15, P: 705-730