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Showing 1–2 of 2 results
Advanced filters: Author: Robert Lohmayer Clear advanced filters
  • The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their circulating counterpart, but share a common origin with intratumoral antigen-experienced conventional T cells.

    • Maria Xydia
    • Raheleh Rahbari
    • Philipp Beckhove
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18
  • Immune disease-associated biomarker values are commonly more variable in affected compared to unaffected patient populations, which limits a biomarker’s informative range. Here, the authors formalise a computational solution that splits datasets into informative and uninformative subsets to improve biomarker discovery and performance of multivariate predictive models.

    • Gunther Glehr
    • Paloma Riquelme
    • James A. Hutchinson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21