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Showing 1–15 of 15 results
Advanced filters: Author: Robert M. Glaeser Clear advanced filters

  • Phase plates improve contrast in cryo-electron microscopy, but suffer from electrostatic charging and electron scattering. A laser phase plate overcomes these problems and may improve imaging of biological specimens.

    • Osip Schwartz
    • Jeremy J. Axelrod
    • Holger Müller
    Research
    Nature Methods
    Volume: 16, P: 1016-1020

  • Single-particle cryo-EM is a powerful method for macromolecular structure determination. Here the authors demonstrate that Ewald sphere curvature correction, sub-Angstrom pixilation and per-particle CTF refinement can improve map quality and resolution and present the 1.86 Å cryo-EM structure of an adeno-associated virus serotype 2 variant.

    • Yong Zi Tan
    • Sriram Aiyer
    • Dmitry Lyumkis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • G-protein-coupled receptors are biological targets for drug discovery. Developments in cryo-electron microscopy have enabled the solution of the structure of a class B receptor in complex with its signalling protein. Two biologists and a microscopist explain the exciting implications of this work. See Article p.118

    • Ching-Ju Tsai
    • Joerg Standfuss
    • Robert M. Glaeser
    News & Views
    Nature
    Volume: 546, P: 36-37

  • The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titrating VEGF via the expression of its trapping receptor sFlt1.

    • Patricia Himmels
    • Isidora Paredes
    • Carmen Ruiz de Almodóvar
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Covalent histone modifications have been linked to many DNA processes. The repertoire of modifications is still growing, and histone H3K64 trimethylation is now shown to be localized to pericentric chromatin and its levels dynamically altered during developmental reprogramming in both embryos and primordial germ cells.

    • Sylvain Daujat
    • Thomas Weiss
    • Robert Schneider
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 777-781

  • Two reports describing the use of direct-conversion electron detectors and algorithms that correct for beam-induced sample motion in single-particle electron cryomicroscopy demonstrate that this technique can solve structures of macromolecules at near-atomic resolution.

    • Robert M. Glaeser
    News & Views
    Nature Methods
    Volume: 10, P: 475-476

  • Social disconnection across socioeconomic lines is explained by both differences in exposure to people with high socioeconomic status and friending bias—the tendency for people to befriend peers with similar socioeconomic status even conditional on exposure.

    • Raj Chetty
    • Matthew O. Jackson
    • Nils Wernerfelt
    ResearchOpen Access
    Nature
    Volume: 608, P: 122-134

  • Cryo-EM has emerged rapidly as a method for determining high-resolution structures of biological macromolecules. The author of this Commentary discusses just how much better this technology may get and how fast such developments are likely to happen.

    • Robert M Glaeser
    Comments & Opinion
    Nature Methods
    Volume: 13, P: 28-32