Nature Search

Defects in t⁶A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome

The biosynthesis of N⁶-threonylcarbamoylated adenosine 37 in tRNA (t⁶A) involves the YRDC enzyme and the KEOPS complex. Here, the authors report mutations in YRDC and the KEOPS component GON7 in Galloway-Mowat syndrome and determine the crystal structure of a GON7-containg subcomplex that suggests a role in KEOPS complex stability.

Christelle Arrondel
Sophia Missoury
Géraldine Mollet
ResearchOpen Access03 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Simultaneous observations of ammonia in the atmosphere and ocean

Patricia K. Quinn
Robert J. Charlson
Timothy S. Bates
Research22 Sept 1988
Nature

Volume: 335, P: 336-338
Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

Meta-analysis of data from 58,265 cattle shows that the genetic architecture underlying stature is similar to that in humans, where many genomic regions individually explain only a small amount of phenotypic variance.

Aniek C. Bouwman
Hans D. Daetwyler
Ben J. Hayes
Research19 Feb 2018
Nature Genetics

Volume: 50, P: 362-367
Punctuation and selection

ROBERT B. ECKHARDT
Research14 Jul 1988
Nature

Volume: 334, P: 110
Oceanic phytoplankton, atmospheric sulphur, cloud albedo and climate

Robert J. Charlson
James E. Lovelock
Stephen G. Warren
Reviews22 Apr 1987
Nature

Volume: 326, P: 655-661
Enhanced CO₂ greenhouse to compensate for reduced solar luminosity on early Earth

TOBIAS OWEN
ROBERT D. CESS
V. RAMANATHAN
Research01 Feb 1979
Nature

Volume: 277, P: 640-642
Hindered bedload settling as a model of sand bed planation by water waves

Robert J. Hallermeier
Research06 May 1982
Nature

Volume: 297, P: 53-55
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Subwavelength coherent imaging of periodic samples using a 13.5 nm tabletop high-harmonic light source

Coherent diffractive imaging of periodic samples is demonstrated with a tabletop, 13.5 nm high-harmonic source. With a novel image reconstruction technique, the record high spatial resolution of 12.6 nm is achieved in the extreme-ultraviolet region.

Dennis F. Gardner
Michael Tanksalvala
Giulia F. Mancini
Research20 Mar 2017
Nature Photonics

Volume: 11, P: 259-263
The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints

David A Thompson
Glenn Belinsky
Karl Münger
Research18 Dec 1997
Oncogene

Volume: 15, P: 3025-3035
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation

Bernhard Lüscher
Erik Christenson
Robert N. Eisenman
Research05 Apr 1990
Nature

Volume: 344, P: 517-522
Suppression of in vitro haematopoiesis following human immunodeficiency virus infection

Robert E. Donahue
Margaret M. Johnson
Jerome E. Groopman
Research01 Mar 1987
Nature

Volume: 326, P: 200-203
Evidence for the climatic role of marine biogenic sulphur

Timothy S. Bates
Robert J. Charlson
Richard H. Gammon
Research24 Sept 1987
Nature

Volume: 329, P: 319-321
Photochemical release of biologically available nitrogen from aquatic dissolved organic matter

Karen L. Bushaw
Richard G. Zepp
Mary Ann Moran
Research30 May 1996
Nature

Volume: 381, P: 404-407
Toluene degradation products in simulated atmospheric conditions

Bruce E. Dumdei
Robert J. O'Brien
Research20 Sept 1984
Nature

Volume: 311, P: 248-250
Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Xia Jiang
Hilary K. Finucane
Sara Lindström
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-23
Ecology: Competition in imaginary worlds

Paul H. Harvey
Robert M. May
News & Views21 Mar 1985
Nature

Volume: 314, P: 228-229
Mapping medically relevant RNA isoform diversity in the aged human frontal cortex with deep long-read RNA-seq

The landscape of RNA isoforms in human cortex is revealed by deep long-read RNA sequencing.

Bernardo Aguzzoli Heberle
J. Anthony Brandon
Mark T. W. Ebbert
ResearchOpen Access22 May 2024
Nature Biotechnology

Volume: 43, P: 635-646
Adipose Tissue Abnormalities in Cystic Fibrosis: Noninvasive Determination of Mono- and Polyunsaturated Fatty Acids by Carbon-13 Topical Magnetic Resonance Spectroscopy

Robert J Dimand
Chrit T W Moonen
Kenneth L Cox
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 243-246
A Dexterous, Glove-Based Teleoperable Low-Power Soft Robotic Arm for Delicate Deep-Sea Biological Exploration

Brennan T. Phillips
Kaitlyn P. Becker
Robert J. Wood
ResearchOpen Access03 Oct 2018
Scientific Reports

Volume: 8, P: 1-9
Implications of immunological heterogeneity of tumours

Robert S. Kerbel
News & Views01 Aug 1979
Nature

Volume: 280, P: 358-359
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis

Blanc et al. uncover how chronic inflammation triggers an epigenetic switch in aged muscle stem cells, leading to iron accumulation and cell death by ferroptosis—offering insights into muscle aging and potential paths for regenerative therapies.

Roméo S. Blanc
Nidhi Shah
Robert T. Dirksen
ResearchOpen Access30 Jun 2025
Nature Aging

Volume: 5, P: 1491-1509
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis

The heterogenous nature of rheumatoid arthritis renders the prediction of responsiveness to biological treatments difficult. Here the authors analyze bulk RNA-seq data from the STRAP trial (n = 208) to build a machine-learning model for predicting responses to etanercept, tocilizumab and rituximab with AUCs around 0.75 to potentially assist in therapy planning.

Myles J. Lewis
Cankut Çubuk
Anne Barton
ResearchOpen Access02 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

TSPO PET imaging is widely used to quantify microglial activation. Here, the authors show that TSPO expression increases in activated rodent but not human microglia, implying that in humans TSPO informs on microglial density rather than activation status.

Erik Nutma
Nurun Fancy
David R. Owen
ResearchOpen Access28 Aug 2023
Nature Communications

Volume: 14, P: 1-25
Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation

Pei-Rung Wu
Shang-Yin Chiang
Ruey-Hwa Chen
ResearchOpen Access21 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-16
Immune responses against SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies: UK PROSECO study

Lim and colleagues present the UK PROSECO study where they assess humoral and cellular immune responses to one, two and three doses of vaccination against SARS-CoV-2 in patients with B-cell malignancies in a prospective observational study.

Sean H. Lim
Beth Stuart
David Goldblatt
ResearchOpen Access24 Mar 2022
Nature Cancer

Volume: 3, P: 552-564
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Extensive host-switching of avian feather lice following the Cretaceous-Paleogene mass extinction event

Robert de Moya et al. use comparative genomics of avian lice to reconstruct the phylogeny of these parasites. They show that feather lice diversified on the common ancestor of waterfowl and landfowl, and then radiated onto other avian lineages through host-switching.

Robert S. de Moya
Julie M. Allen
Kevin P. Johnson
ResearchOpen Access29 Nov 2019
Communications Biology

Volume: 2, P: 1-6
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Deuterium in the Galactic Centre as a result of recent infall of low-metallicity gas

D. A. Lubowich
Jay M. Pasachoff
Robert P. Galloway
Research29 Jun 2000
Nature

Volume: 405, P: 1025-1027
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor

Clare Turnbull and colleagues report discovery of 19 new susceptibility loci for testicular germ cell tumor (TGCT) and provide evidence for a network of physical interactions between TGCT risk variants and candidate causal genes. Their findings implicate widespread disruption of developmental transcriptional regulators in TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating step in oncogenesis.

Kevin Litchfield
Max Levy
Clare Turnbull
Research12 Jun 2017
Nature Genetics

Volume: 49, P: 1133-1140
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis

Sarcoidosis is a heterogenous disorder often treated with glucocorticoids. Here the authors show, in an open label, non-randomized, single arm clinical trial involving 10 patients, that treatment with tofacitinib, a Janus kinase inhibitor, is associated with improved clinical symptoms and reduced activity of Th1 cytokines such as IFN-γ and IL-12.

William Damsky
Alice Wang
Brett King
ResearchOpen Access06 Jun 2022
Nature Communications

Volume: 13, P: 1-17
Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner

Susan M. Galloway
Kenneth P. McNatty
Olli Ritvos
Research01 Jul 2000
Nature Genetics

Volume: 25, P: 279-283
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells

Christine C Zhang
Jin-Ming Yang
William N Hait
Research01 Apr 1998
Oncogene

Volume: 16, P: 1617-1624
Latitudinal limits to the predicted increase of the peatland carbon sink with warming

Analysis of peatland carbon accumulation over the last millennium and its association with global-scale climate space indicates an ongoing carbon sink into the future, but with decreasing strength as conditions warm.

Angela V. Gallego-Sala
Dan J. Charman
Yan Zhao
Research10 Sept 2018
Nature Climate Change

Volume: 8, P: 907-913
Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells

Ted Hung-Tse Chang
F Andrew Ray
Robert Schlegel
Research22 May 1997
Oncogene

Volume: 14, P: 2383-2393
Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1

Turner and colleagues show that the RNA-binding protein ZFP36L1 regulates a post-transcriptional hub that determines the identity of marginal-zone B cells by promoting their localization and survival.

Rebecca Newman
Helena Ahlfors
Martin Turner
Research10 Apr 2017
Nature Immunology

Volume: 18, P: 683-693
THE GROUP B STREPTOCOCCUS (GBS) AND COMPLEMENT (C) ACTIVATION: CLINICAL AND LABORATORY CORRELATES WITH GRAM NEGATIVE SEPSIS

Lawrence J Fenton
Robert C Strunk
Grant Morrow III
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 499
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Carla Grandori
Natividad Gomez-Roman
Robert J. White
Research20 Feb 2005
Nature Cell Biology

Volume: 7, P: 311-318
A phase II trial of induction and consolidation therapy of acute myeloid leukemia with weekly oral idarubicin alone in poor risk elderly patients

R Bouabdallah
F Lefrère
P Fenaux
Research07 Oct 1999
Leukemia

Volume: 13, P: 1491-1496
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Renal Function Studies and Kidney Pyruvate Garboxylase in Subacute Necrotizing Encephalomyelopathy (Leigh's Syndrome)

Alan B Gruskin
Mulchand S Patel
Warren Grover
Research01 Oct 1973
Pediatric Research

Volume: 7, P: 832-841
Ocean acidification increases copper toxicity differentially in two key marine invertebrates with distinct acid-base responses

Ceri Lewis
Robert P. Ellis
Rod W. Wilson
ResearchOpen Access22 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Voxel size and gray level normalization of CT radiomic features in lung cancer

Muhammad Shafiq-ul-Hassan
Kujtim Latifi
Eduardo Moros
ResearchOpen Access12 Jul 2018
Scientific Reports

Volume: 8, P: 1-9
Safety of biologic therapy in rheumatoid arthritis

Biologic therapies, which have transformed the treatment of rheumatoid arthritis (RA) in the 21^stCentury, have the potential to modulate immune responses and thus are associated with a risk of infection, as well as other adverse events. This Review summarizes the available safety data for all such agents approved for the treatment of RA, to assist clinicians in weighing potential risks and therapeutic benefits.

Robert S. Woodrick
Eric M. Ruderman
Reviews11 Oct 2011
Nature Reviews Rheumatology

Volume: 7, P: 639-652

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