Nature Search

Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon

In this study, the authors identify inhibitory brainstem neurons that innervate the entire spinal cord as parts of a descending pain-inhibits-pain circuit. Their activation causes body-wide analgesia, while silencing induces pain in response to innocuous stimuli.

Robert P. Ganley
Marília Sousa
Hanns Ulrich Zeilhofer
ResearchOpen Access02 Apr 2026
Nature Communications

P: 1-18
Population genomics of domestic and wild yeasts

David Carter
Gianni Liti
Edward Louis
ResearchOpen Access20 Jun 2008
Nature Precedings

P: 1
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

Gabriele Civiletto
Dario Brunetti
Philipp Gut
ResearchOpen Access24 Sept 2025
Nature Aging

Volume: 5, P: 2003-2021
Prevalence and Dynamics of Ribosomal DNA Micro-heterogeneity Are Linked to Population History in Two Contrasting Yeast Species

Stephen A. James
Claire West
Ian N. Roberts
ResearchOpen Access27 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.

Linda Sawade
Federica Grandi
Volker Haucke
ResearchOpen Access05 Jun 2020
Nature Communications

Volume: 11, P: 1-18
Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons

Anthony R. Anzell
Garrett M. Fogo
Thomas H. Sanderson
ResearchOpen Access12 May 2021
Cell Death & Disease

Volume: 12, P: 1-15
Missing the mark? Identifying child sexual abuse material forum structure and key-players based on public replies and private messaging networks

Frederic M. Gnielka
Rebecca Reichel
Robert J. B. Lehmann
ResearchOpen Access02 Nov 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-15
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE

James B. Rottman
Tammy Smith
Anthony J. Coyle
Research01 Jul 2001
Nature Immunology

Volume: 2, P: 605-611
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

The enzyme O-GlcNAc transferase harbours a new type of lipid binding site; overexpression of the enzyme in the liver of mice causes insulin resistance and dyslipidaemia, underscoring the pivotal contribution of sugar modifications to insulin resistance and type 2 diabetes.

Xiaoyong Yang
Pat P. Ongusaha
Ronald M. Evans
Research21 Feb 2008
Nature

Volume: 451, P: 964-969
A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

PPARγ induces fibroblast growth factor 1 to remodel visceral adipose tissue in response to a high-fat diet to maintain metabolic homeostasis.

Johan W. Jonker
Jae Myoung Suh
Ronald M. Evans
Research22 Apr 2012
Nature

Volume: 485, P: 391-394

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