Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–10 of 10 results
Advanced filters: Author: Robert Sarpong Clear advanced filters

  • We present a synthetic method that transforms complex pyrimidine-containing structures into iminoenamines and then uses de novo heterocycle synthesis to obtain substituted pyrimidine and 1,2-azole analogues.

    • Benjamin J. H. Uhlenbruck
    • Celena M. Josephitis
    • Andrew McNally
    Research
    Nature
    Volume: 631, P: 87-93

  • Strategies that utilize the oxidation of unactivated C–H bonds are becoming increasingly popular in natural product total synthesis. This Review classifies and highlights the different strategic use-cases of oxidation reactions as they were applied in recent total syntheses.

    • Ian Bakanas
    • Robert F. Lusi
    • Richmond Sarpong
    Reviews
    Nature Reviews Chemistry
    Volume: 7, P: 783-799

  • Many natural products exist as families of structurally similar molecules, and therefore developing skeletal modifications of common intermediates offers flexible and powerful approaches for target synthesis. Here, the authors report a single-atom insertion into the framework of the benzenoid subfamily, providing access to the troponoid congeners.

    • Stefan Wiesler
    • Goh Sennari
    • Richmond Sarpong
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • Generating strategies that use modern synthetic methods to access privileged chemical space is a central goal of total synthesis. Now, a strategy that is orthogonal to classic approaches, coupled with C–H functionalization methods, leads to the shortest synthesis of the sesquiterpenoid longiborneol and divergent syntheses of oxygenated longiborneol congeners.

    • Robert F. Lusi
    • Goh Sennari
    • Richmond Sarpong
    Research
    Nature Chemistry
    Volume: 14, P: 450-456

  • Typhoid fever is caused by the bacterium Salmonella Typhi. Here, Park et al. analyse the genomes of 249 S. Typhi isolates from 11 sub-Saharan African countries, identifying genes and plasmids associated with antibiotic resistance and showing that multi-drug resistance is highly pervasive in sub-Saharan Africa.

    • Se Eun Park
    • Duy Thanh Pham
    • Stephen Baker
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

    • Eric A. Collisson
    • Joshua D. Campbell
    • Ming-Sound Tsao
    ResearchOpen Access
    Nature
    Volume: 511, P: 543-550

  • While 2000-2019 Snow Water Availability increased, nearly 3% of Canada and Alaska, particularly in the North American Cordillera, underwent significant losses. Along with other insignificant losses, water supply for 86% of Canadians is threatened.

    • Robert Sarpong
    • Ali Nazemi
    • Amir AghaKouchak
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 7, P: 1-16

  • Allosteric small-molecule inhibitors of the p53-induced oncogenic phosphatase Wip1 bind at a ‘flap’ subdomain near the catalytic site. Inhibitor GSK2830371 inhibits the phosphatase and oncogenic activities in cell lines and a xenograft tumor model.

    • Aidan G Gilmartin
    • Thomas H Faitg
    • Rakesh Kumar
    Research
    Nature Chemical Biology
    Volume: 10, P: 181-187