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Showing 1–7 of 7 results
Advanced filters: Author: Robert Siddaway Clear advanced filters

  • In a prospective study including 2,300 pediatric and adult patients with liquid and solid tumors, RNA sequencing provided actionable molecular information in 87% of cases, with applications in diagnostics and therapy matching.

    • Robert Siddaway
    • Aida I. Glembocki
    • Cynthia Hawkins
    Research
    Nature Medicine
    Volume: 31, P: 3524-3533

  • Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse tumorigesis on its own, acting through a RAS/MYC transcriptomic programme.

    • Sanja Pajovic
    • Robert Siddaway
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Targeting genetic drivers of high grade diffuse glioma (HGG) has not improved patient survival, suggesting the involvement of other mechanisms. Here, across cancer types, the authors identify increased alternative splicing burden in cancer drivers compared to mutation rate as an alternative mechanism for activation of oncogenic pathways such as RAS/MAPK.

    • Robert Siddaway
    • Scott Milos
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.

    • Ana S. Guerreiro Stucklin
    • Scott Ryall
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The tumour immune microenvironment remains poorly characterised in paediatric brain tumours. Here, the authors develop a clinical immune-oncology gene expression assay to profile 1382 paediatric brain tumour samples, and reveal immune profiles and biomarkers that can contribute to diagnosis, prognosis, and treatment response.

    • Adrian B. Levine
    • Liana Nobre
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The c-Jun transcription factor can mediate a cell's response to TNFa. Here, Riesenberg et al. show in melanoma cells that c-Jun has an inverse relationship with the key melanocyte transcription factor MITF and that high c-Jun levels contribute to melanoma heterogeneity and an inflammatory microenvironment.

    • Stefanie Riesenberg
    • Angela Groetchen
    • Michael Hölzel
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-16