In osteoarthritis (OA), chronic, low-grade inflammatory processes promote the symptoms and progression of the disease. In this Review, the authors discuss the inflammatory pathophysiology in OA, including networks of inflammatory mediators in OA joints, transcriptional reprogramming of chondrocytes, and abnormal bioenergetics and proteostasis mechanisms, and consider the potential to target these processes for the treatment of OA.
- Ru Liu-Bryan
- Robert Terkeltaub
