Multiple sclerosis (MS) is an inflammatory disorder of the CNS, with downstream effects on body structures and function, and patient activities, as outlined in the International Classification of Functioning, Disability and Health (ICF) model of MS. Focusing on the ICF outcomes, Motl and Pilutti review evidence regarding the benefits of exercise training in patients with MS, highlighting the mechanistic pathways that may mediate these effects, and discussing issues and future research in this field.
- Robert W. Motl
- Lara A. Pilutti
