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Showing 1–2 of 2 results
Advanced filters: Author: Roberta Carloni Clear advanced filters

  • Decoding the role of inter-chromosomal DNA-DNA interactions remains challenging. Here, the authors use Micro-C to study the T. brucei genome architecture at high resolution and reveal an intricate network of inter-chromosomal transcription hub structures.

    • Claudia Rabuffo
    • Markus R. Schmidt
    • T. Nicolai Siegel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Human tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs covalently trapped topoisomerase 1B-DNA complexes and other lesions, and is a target for anticancer drug development. Here the authors use an integrated structural approach to shed light onto the molecular basis of DNA end-processing by Tdp1.

    • Fiona J. Flett
    • Emilija Ruksenaite
    • Julia M. Richardson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13