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Advanced filters: Author: Roberto Bosotti Clear advanced filters

  • Human primary and metastatic tumors harbor CD4+ Treg cells that can suppress antitumor immune responses. Bonnal et al. identify an intratumoral type 1 Treg-like CD4+ T cell subset that expresses the transcription factor EOMES, granzyme K and CHI3L2. This EOMES+ T cell subset correlates with disease progression but is responsive to PD-1 checkpoint blockade immunotherapy.

    • Raoul J. P. Bonnal
    • Grazisa Rossetti
    • Massimiliano Pagani
    Research
    Nature Immunology
    Volume: 22, P: 735-745