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Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents

Cristina M. Alberini
Paola Bet
Roberto Sitia
Research04 Oct 1990
Nature

Volume: 347, P: 485-487
Europe must become a research epicentre as US system gets undermined

Anna Rubartelli
Valeria Poli
Roberto Sitia
Correspondence22 Apr 2025
Nature

Volume: 640, P: 881
Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

Zinc ions (Zn²⁺) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn²⁺ regulates protein quality control in the early secretory pathway by demonstrating that the pH-sensitive chaperone ERp44 binds Zn²⁺ and solving the Zn²⁺-bound ERp44 structure.

Satoshi Watanabe
Yuta Amagai
Kenji Inaba
ResearchOpen Access05 Feb 2019
Nature Communications

Volume: 10, P: 1-16
Biochemical nature of Russell Bodies

Maria Francesca Mossuto
Diletta Ami
Roberto Sitia
ResearchOpen Access30 Jul 2015
Scientific Reports

Volume: 5, P: 1-12
Changes in gene expression during the growth arrest of HepG2 hepatoma cells induced by reducing agents or TGFβ1

Andrea Cabibbo
G Giacomo Consalez
Anna Rubartelli
Research09 Jun 1998
Oncogene

Volume: 16, P: 2935-2943
Author Correction: Zinc homeostasis governed by Golgi-resident ZnT family members regulates ERp44-mediated proteostasis at the ER-Golgi interface

Yuta Amagai
Momo Yamada
Kenji Inaba
Amendments and CorrectionsOpen Access12 Jun 2023
Nature Communications

Volume: 14, P: 1
Chemo-metabolic regulation of immune responses by Tregs

Chemo-metabolic processes such as redox remodeling and amino acid availability act as immunity rheostats, revealing a new mechanism regulating intercellular cross-talk between dendritic cells, regulatory T lymphocytes and effector T lymphocytes.

Anna Rubartelli
Roberto Sitia
News & Views01 Oct 2009
Nature Chemical Biology

Volume: 5, P: 709-710
Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway

Chiara Giannone
Claudio Fagioli
Tiziana Anelli
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Monitoring cytosolic H₂O₂ fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

Reliable methods of measuring intracellular H₂O₂ fluctuations are necessary to advance redox biology. Here the authors design a H₂O₂ sensor based on the fission yeast peroxiredoxin Tpx1 to sense nanomolar fluctuations of intracellular H₂O₂ in response to genetic and environmental perturbations.

Mercè Carmona
Laura de Cubas
Elena Hidalgo
ResearchOpen Access04 Oct 2019
Nature Communications

Volume: 10, P: 1-13
Zinc homeostasis governed by Golgi-resident ZnT family members regulates ERp44-mediated proteostasis at the ER-Golgi interface

Zinc is vital to protein quality control in the early secretory pathway. Here, authors demonstrate distinct roles of the Golgi-resident zinc transporters for the maintenance of zinc homeostasis and the regulation of a zinc-dependent chaperone, ERp44.

Yuta Amagai
Momo Yamada
Kenji Inaba
ResearchOpen Access09 May 2023
Nature Communications

Volume: 14, P: 1-18
Quality control in the endoplasmic reticulum protein factory

Roberto Sitia
Ineke Braakman
Reviews18 Dec 2003
Nature

Volume: 426, P: 891-894
Plasma cells require autophagy for sustainable immunoglobulin production

Plasma cells are antibody 'factories', which places considerable metabolic stress on these cells. Cenci and colleagues show that long-lived plasma cells and sustained antibody production require autophagy activation.

Niccolò Pengo
Maria Scolari
Simone Cenci
Research27 Jan 2013
Nature Immunology

Volume: 14, P: 298-305
Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

Claudia Semino
Sonia Carta
Anna Rubartelli
ResearchOpen Access23 Oct 2018
Cell Death & Disease

Volume: 9, P: 1-14
Chronic hepatitis B: role of anti-platelet therapy in inflammation control

Roberto Aiolfi
Giovanni Sitia
Reviews12 Jan 2015
Cellular & Molecular Immunology

Volume: 12, P: 264-268
Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

Edgar Djaha Yoboue
Roberto Sitia
Thomas Simmen
ReviewsOpen Access28 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-14

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