Meng et al. develop the adeno-associated virus 9-based therapy CM-YAPon to transiently and inducibly express YAP in the heart. In mice, CM-YAPon promoted cardiomyocyte cell cycle reentry and reprogrammed the cardiac microenvironment. The CM-YAPon gene therapy improved cardiac function after myocardial infarction (MI) and conferred cardioprotection before MI.
- Fansen Meng
- Jeffrey D. Steimle
- James F. Martin
