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Advanced filters: Author: Robin Fertig Clear advanced filters

Rational design of N-heterocyclic compound classes via regenerative cyclization of diamines

Introducing unknown compound classes is the key to extent the chemical space qualitatively. Here the authors report on a concept to design heterocyclic compound classes rationally and the synthesis of unknown classes of N-heterocyclic compounds

Robin Fertig
Felix Leowsky-Künstler
Rhett Kempe
ResearchOpen Access03 Feb 2023
Nature Communications

Volume: 14, P: 1-10
Endothelial struts enable the generation of large lumenized blood vessels de novo

Weijts et al. present a model of vasculogenesis in zebrafish whereby endothelial cells form a network of struts, allowing de novo formation of large-diameter blood vessels without a vascular cord or hollowing step.

Bart Weijts
Iftach Shaked
David Traver
Research09 Apr 2021
Nature Cell Biology

Volume: 23, P: 322-329

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Rational design of N-heterocyclic compound classes via regenerative cyclization of diamines

Endothelial struts enable the generation of large lumenized blood vessels de novo

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