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Showing 1–5 of 5 results
Advanced filters: Author: Robin Goland Clear advanced filters

  • Nuclear genome transfer using unfertilized donor oocytes is performed and shown to be effective in preventing the transmission of mitochondrial DNA mutations; the swapped oocytes can develop to the blastocyst stage, and produce parthenogenetic embryonic stem-cell lines that show normal karyotypes and only mitochondrial DNA from the donor oocyte.

    • Daniel Paull
    • Valentina Emmanuele
    • Dieter Egli
    Research
    Nature
    Volume: 493, P: 632-637

  • The generation of human cell lines using somatic cell nuclear transfer has been difficult to achieve. In this study, Egliet al. show that while mouse eggs reprogram somatic cells within hours, human eggs arrest after nuclear transfer which may be due to a lack of genome transcription.

    • Dieter Egli
    • Alice E. Chen
    • Kevin Eggan
    Research
    Nature Communications
    Volume: 2, P: 1-10

  • hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretion, demonstrating a basis to treat HNF1A-MODY patients with sulfonylureas.

    • Bryan J. González
    • Haoquan Zhao
    • Dieter Egli
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-17