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Showing 1–9 of 9 results
Advanced filters: Author: Robyn M. Kaake Clear advanced filters

  • Polyketide synthase 13 from mycobacteria was purified endogenously ‘in action’ with wild-type substrates bound. Structures by cryo-EM define multiple states of acyl carrier proteins in the final step of mycolic acid synthesis by a key drug target.

    • Sun Kyung Kim
    • Miles Sasha Dickinson
    • Robert M. Stroud
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 296-308

  • Using a multi-OMICS approach, Haas et al identify 54 human genes and 16 host-targeting chemical compounds that regulate influenza A virus infection in lung epithelial cells, including AHNAK and COBP1 which are also essential for SARS-CoV-2 infection.

    • Kelsey M. Haas
    • Michael J. McGregor
    • Nevan J. Krogan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-27

  • A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

    • David E. Gordon
    • Gwendolyn M. Jang
    • Nevan J. Krogan
    Research
    Nature
    Volume: 583, P: 459-468

  • Crystallography and mutagenesis analyses examine how HIV-1 Nef interacts with AP2 to enable CD4 binding and downregulation and reveal the role of a Nef pocket that is also involved in downregulation of class I MHC.

    • Yonghwa Kwon
    • Robyn M. Kaake
    • Xiaofei Jia
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 822-828

  • Perez-Bermejo et al. performed an in-depth study on a variant in the BAG3 gene that has been previously associated with lowered incidence of heart failure and show that, in induced pluripotent stem cell-derived cardiomyocytes engineered to express such BAG3 variant, the interactome of the corresponding BAG3 protein has changed, rendering the engineered cardiomyocytes more resistant to a well-known cardiotoxic drug.

    • Juan A. Perez-Bermejo
    • Luke M. Judge
    • Bruce R. Conklin
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 615-628

  • Large-scale genetic datasets and deep learning approaches are being used to model the structures of proteins or protein complexes. This Review describes approaches based on coevolution, deep mutational scanning and genome-scale genetic or chemical–genetic interaction mapping and their application and integration to inform structural modelling.

    • Hannes Braberg
    • Ignacia Echeverria
    • Nevan J. Krogan
    Reviews
    Nature Reviews Genetics
    Volume: 23, P: 342-354

  • This Review outlines a broad, universal framework for systems biology applied to infectious disease research. From study design and omics data collection, analysis, visualization and interpretation to translational outcomes, the authors illustrate how systems biology can provide insights into host–pathogen relationships for the betterment of human health.

    • Manon Eckhardt
    • Judd F. Hultquist
    • Nevan J. Krogan
    Reviews
    Nature Reviews Genetics
    Volume: 21, P: 339-354