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Showing 1–11 of 11 results
Advanced filters: Author: Roderick J. O’Sullivan Clear advanced filters

  • Some cancer cells lacking telomerase activity extend their telomeres via an alternative, recombination-based mechanism, termed ALT. A new study shows that depletion of histone chaperone ASF1 can induce ALT in both primary and cancer cells, suggesting that the ALT pathway may be triggered by changes in chromatin state.

    • Roderick J O'Sullivan
    • Nausica Arnoult
    • Jan Karlseder
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 167-174

  • Telomeres are endogenous cellular targets of DNA ADP-ribosylation (DNA-ADPr). TARG1-regulated DNA-ADPr is coupled to lagging telomere DNA strand synthesis, and persistent DNA-ADPr, due to TARG1 deficiency, leads to telomere shortening and fragility.

    • Anne R. Wondisford
    • Junyeop Lee
    • Roderick J. O’Sullivan
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 791-800

  • Two single-stranded DNA-binding proteins, POT1 and RPA, associate with telomeres. Binding of RPA to telomeres can activate a DNA damage response, so it was previously proposed that POT1 binds telomeres to prevent RPA association. Here, it is found that POT1–TPP1 cannot prevent RPA binding, and hnRNPA1 is identified as having this activity instead. In addition, it is shown that TERRA, a telomere-associated RNA, displaces hnRNPA1 and promotes POT1 binding after S phase, when replication is completed.

    • Rachel Litman Flynn
    • Richard C. Centore
    • Lee Zou
    Research
    Nature
    Volume: 471, P: 532-536

  • Proteomic definition of the telomeric PARylome combined with genetic and histone H3.3 deposition assays at telomeres reveals that PAR-regulated HIRA activity compensates for loss of ATRX in ALT cells.

    • Song My Hoang
    • Nicole Kaminski
    • Roderick J. O’Sullivan
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 1152-1164

  • Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

    • Peter Sandercock
    • Janet Darbyshire
    • Martin J. Landray
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Telomere shortening, senescence and aging are connected, but how the signal at shortening telomeres is transmitted to the cell more globally is unclear. H3 and H4 synthesis is now shown to be reduced as cell cultures age. This alters expression of Asf1, a histone chaperone, compromising the ability of aging cells to restore chromatin after replication and DNA. In this way localized effects at shortening telomeres can be propagated throughout the cell.

    • Roderick J O'Sullivan
    • Stefan Kubicek
    • Jan Karlseder
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1218-1225

  • An unstable genome is a hallmark of many cancer cells. Telomeres prevent the ends of linear chromosomes from being recognized as damaged DNA, thus protecting them from DNA repair mechanisms and inhibiting the breakage–fusion–bridge cycles that cause genome instability.

    • Roderick J. O'Sullivan
    • Jan Karlseder
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 171-181