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Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Amazonian fog samples contain viable microbes, suggesting fog plays a role microbial dispersal, colonization and nutrient cycling, according to analyses of fog samples from a tall tower observatory.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Despite its impressive mechanical and electronic properties, graphene’s magnetic characteristics are poor. However, adsorbed organic molecules can give the material magnetic functionality, and the magnetic moment remains when the molecules combine to form dimers or even a continuous monolayer.

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

Wood density is a key control on tree biomass, and understanding its spatial variation improves estimates of forest carbon stock. Sullivan et al. measure >900 forest plots to quantify wood density and produce high resolution maps of its variation across South American tropical forests.

Inventory data from more than 1 million trees across African, Amazonian and Southeast Asian tropical forests suggests that, despite their high diversity, just 1,053 species, representing a consistent ~2.2% of tropical tree species in each region, constitute half of Earth’s 800 billion tropical trees.

Analysis of ground-sourced and satellite-derived models reveals a global forest carbon potential of 226 Gt outside agricultural and urban lands, with a difference of only 12% across these modelling approaches.

High-resolution drone data can enhance sustainable forest management. Here, authors demonstrate a cost-effective method using drones and deep learning to map and manage economically important palm species in the Peruvian Amazon, significantly reducing inventory costs and time.

Functional profiling of enzyme family classes is essential for clinical tissue phenotyping. Here, the authors develop and apply an alternative approach in activity-based protein profiling of serine hydrolases, revealing molecular layers of catalytic enzyme fractions involved in palmitate remodeling and lung adenocarcinoma progression.

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

The authors analyse tree responses to an extreme heat and drought event across South America to understand long-term climate resistance. While no more sensitive to this than previous lesser events, forests in drier climates showed the greatest impacts and thus vulnerability to climate extremes.

The role of non-structural carbohydrates (NSC) in mediating the impacts of drought in tropical trees is unclear. Here, the authors analyse leaf and branch NSC in 82 Amazon tree species across a Basin-wide precipitation gradient, finding that allocation of leaf NSC to soluble sugars is higher in drier sites and is coupled to tree hydraulic status.

Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.

Inventory data from 90 lowland Amazonian forest plots and a phylogeny of 526 angiosperm genera were used to show that taxonomic and phylogenetic diversity are both predictive of wood productivity but not of biomass variation.

A pan-Amazon study of forests shows large variations in drought tolerance traits and finds that forests in regions of pronounced climate change are losing biomass and may be operating beyond their hydraulic limits.

Antigen-specific CD8⁺ T cells can be imaged by immunoPET with the help of synTacs, MHC-based tools that bind to relevant T-cell receptors.

A new study shows that deforestation of Amazon mangroves releases up to four times more carbon dioxide when compared to emissions arising from terrestrial biomes. This study set a foundation for the use of mangroves in Brazil’s international policy agreements.

The ecological impact of ocean acidification as a result of climate change is difficult to predict. A natural CO₂ venting site is used here to demonstrate the shifts occurring in a rocky shore marine community as a result of a pH gradient.

Tree mortality has been shown to be the dominant control on carbon storage in Amazon forests, but little is known of how and why Amazon forest trees die. Here the authors analyse a large Amazon-wide dataset, finding that fast-growing species face greater mortality risk, but that slower-growing individuals within a species are more likely to die, regardless of size.

JWST observations of the planetary nebula NGC 3132 reveal a rich molecular environment containing evidence of multiple stellar interactions on a variety of scales.

Emerging SARS-CoV-2 variants of concern were detected early and multiple cases of virus spread not captured by clinical genomic surveillance were identified using high-resolution wastewater and clinical sequencing.

Interfaces between organic molecules and metal surfaces have a key role in determining the performance of many emerging technologies. Now an intensive experimental study — supported by calculations — of tetracyano-p-quinodimethane molecules on a copper surface, reveals structural rearrangement of both the organic molecules and the surface atoms after charge transfer across the interface.

Only praziquantel is available for treating schistosomiasis, a disease affecting >200 million people. Here, the authors identify compounds active against schistosome infections meeting the criteria for lead progression indicated by WHO with better activity against juvenile worms than praziquantel.

The synthesis of polycyclic conjugated hydrocarbons with antiaromatic moieties is realized by the thermal rearrangement of dibromomethylene-functionalized molecular precursors on a hot Au(111) metal surface.

Meta-analysis of 36,760 cases and 375,188 controls identifies 54 loci associated with susceptibility to cutaneous melanoma. Further analysis combining nevus count and hair color GWAS results provide insights into the genetic architecture of melanoma.

Molecular electronics represents an avenue to enrich conventional electronics, but its reproducibility and scalability are still challenging. Here, the authors report the realization of multifunctional hybrid molecular graphene field effect transistors enabling operando spectroscopy and the implementation of optoelectronic logic gates.

Diseases can be associated with various mutations of the same gene, but the molecular consequences of specific mutations remain incompletely understood. Here, the authors present an integrated proteomic workflow to determine the molecular response of cells to different cancer-associated mutations of the kinase Dyrk2.

Palaeoproteomics offers an opportunity to resolve molecular phylogenies especially in contexts where ancient DNA does not preserve. Here collagen sequences resolve sloth phylogenies differently from morphology-based estimates, illuminating the utility of proteomics in systematics.

Multivalent display of integrin antagonists enhances their efficacy, but current synthetic scaffolds used to display ligands are limited in range and precision. Englundet al. develop a new scaffold to study the multivalent effects of integrin antagonists across wide ranges of ligand number, density, and 3D arrangement.

Functionalizing antimicrobial peptides with fluorescent groups is a useful strategy for imaging infection, but the tag can alter the performance of the probe. Here, the authors report a spacer-free method to directly functionalise an amino acid with a fluorogenic group and prepare peptide-based imaging agents for fungal infection.

Integrating inventory data with machine learning models reveals the global composition of tree types—needle-leaved evergreen individuals dominate, followed by broadleaved evergreen and deciduous trees—and climate change risks.

The human voltage-gated proton channel (hHv1) maintains intracellular pH and membrane potential in sperm and neutrophils. Here, the authors show that albumin activates hHv1, by binding to the channel voltage sensor domains to enhance open probability and increases proton current, and that activation is required to trigger sperm to allow oocyte fertilization and to sustain production and release of immune inflammatory mediators during the neutrophil respiratory burst.

Development of strategies for the synthesis of pi-conjugated polymers is hampered by limited solubility. Here, the authors report a synthetic protocol based on the search for specific vibrational modes through an appropriate tailoring of the p-conjugation of the precursors, in order to increase the attempt frequency of a chemical reaction.

Global patterns of regional plant diversity are relatively well known, but whether they hold for local communities is debated. This study created multi-grain global maps of alpha diversity for vascular plants to provide a nuanced understanding of plant diversity hotspots and improve predictions of global change effects on biodiversity.

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Disentangling the radiative and non-radiative plasmon mode contributions to the total photonic density of states is a challenge. Here, the authors report a procedure to eliminate the electronic-structure factors from scanning tunnelling microscope luminescence spectra to isolate the radiative component.

Polymers commonly are semiconducting or insulating because of a sizable energy gap in the density of states around the Fermi level. Yet, the phase transition from topologically trivial to non-trivial in on-surface synthesized π-conjugated polymers, due to a change of resonant form, stabilizes narrow bandgaps and bears in-gap zero-energy edge states in the non-trivial phase.

Ocean acidification poses a threat to marine calcifiers, but their response varies widely. An analysis of Mediterranean corals and molluscs now shows that the ability to continue shell and skeleton growth in corrosive seawater is determined in part by the existence of outer organic protective layers. High temperatures, however, modify resistance to acidification.

Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imaging of apoptotic cells.