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Showing 1–6 of 6 results
Advanced filters: Author: Rodrigo Fernandez-Gonzalez Clear advanced filters

  • A cable-like ring of biopolymers helps to pull cells together across the site of a wound. Widely thought to be homogeneous, the traction forces involved are actually remarkably heterogeneous — revealing an unexpected pattern of force generation during wound repair.

    • Miranda V. Hunter
    • Rodrigo Fernandez-Gonzalez
    News & Views
    Nature Physics
    Volume: 10, P: 626-627

  • The motor proteins and contractile forces involved in wound closure are both shown to be heterogeneously distributed around a wound. Theory suggests that this heterogeneity speeds up wound closure, as long as the proteins are mechanically regulated.

    • Teresa Zulueta-Coarasa
    • Rodrigo Fernandez-Gonzalez
    Research
    Nature Physics
    Volume: 14, P: 750-758

  • The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and zebrafish models.

    • Shin-Haw Lee
    • Sina Hadipour-Lakmehsari
    • Anthony O. Gramolini
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • Hopyan and colleagues show that tension in the mesoderm and ectoderm leads to formation of a stress pattern that drives the rearrangements of ectodermal cells during limb bud morphogenesis in mouse embryos.

    • Kimberly Lau
    • Hirotaka Tao
    • Sevan Hopyan
    Research
    Nature Cell Biology
    Volume: 17, P: 569-579

  • Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin.

    • Noboru Ishiyama
    • Ritu Sarpal
    • Mitsuhiko Ikura
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17