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Showing 1–3 of 3 results
Advanced filters: Author: Roelof Ottenhoff Clear advanced filters
  • The transcription factor SREBP is a well-studied and major regulator of sterol and fatty acid metabolism. Here, the authors used haploid genetic screens to identify the Golgi-resident protein SPRING as a new modulator of SREBP by regulating the level of functional SREBP cleavage-activating protein (SCAP).

    • Anke Loregger
    • Matthijs Raaben
    • Noam Zelcer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Fluorescent high-affinity activity-based probes used to monitor the activity and presence of active glucocerebrosidase in vitro and in vivo help in understanding Gaucher disease and its treatment with pharmacological chaperones.

    • Martin D Witte
    • Wouter W Kallemeijn
    • Johannes M F G Aerts
    Research
    Nature Chemical Biology
    Volume: 6, P: 907-913