Nature Search

Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy

Prodrug ionizable lipid nanoparticles co-delivering an effector T cell stimulant and a T cell exhaustion inhibitor eliminate primary and distal tumours, offering a potent strategy for combination cancer immunotherapy.

Qiangqiang Shi
Ningqiang Gong
Michael J. Mitchell
Research18 Mar 2026
Nature Nanotechnology

Volume: 21, P: 430-442
Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

Ningqiang Gong
Dongyoon Kim
Michael J. Mitchell
Amendments and Corrections31 Jul 2025
Nature Biomedical Engineering

Volume: 9, P: 2215
Publisher Correction: Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

Kelsey L. Swingle
Alex G. Hamilton
Michael J. Mitchell
Amendments and Corrections03 Feb 2025
Nature

Volume: 638, P: E33
Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

The combinatorial synthesis of ionizable lipids allows for the identification of an antioxidant lipid exhibiting low immunogenicity for lipid nanoparticle-mediated mRNA delivery in vivo.

Ningqiang Gong
Dongyoon Kim
Michael J. Mitchell
Research18 Jul 2025
Nature Biomedical Engineering

Volume: 9, P: 2181-2195
Engineering considerations for paediatric drug delivery

Designing therapeutics for children requires careful consideration of age-dependent anatomy, physiology and immunology. This Review discusses the engineering and optimization of drug delivery systems for paediatric microenvironments to prevent, treat and cure childhood diseases.

Rohan Palanki
William H. Peranteau
Michael J. Mitchell
Reviews12 Mar 2026
Nature Reviews Bioengineering

P: 1-18
Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution

Directed chemical evolution can iteratively accelerate the structural optimization of ionizable lipids to improve their delivery activity and biodegradability for applications in lipid nanoparticle-mediated mRNA delivery.

Xuexiang Han
Mohamad-Gabriel Alameh
Michael J. Mitchell
Research22 Nov 2024
Nature Biomedical Engineering

Volume: 8, P: 1412-1424
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors

Branched ionizable lipids have aroused great interest for mRNA delivery. Here, the authors devise an in situ construction method for combinatorial synthesis of degradable branched ionizable lipids and summarize key design criteria to enable potent delivery of mRNA therapeutics and gene editors.

Xuexiang Han
Junchao Xu
Michael J. Mitchell
ResearchOpen Access26 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric disorders and women’s health.

Kelsey L. Swingle
Alex G. Hamilton
Michael J. Mitchell
Research11 Dec 2024
Nature

Volume: 637, P: 412-421
Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery

mRNA delivery through LNPs targeting specific organs holds great clinical potential, but it remains unclear how the structure of the lipidoids in the LNPs controls organ tropism. Here the authors direct in vivo delivery of siloxane-based LNPs via structural alteration of the ionizable structure of the constituting lipidoids.

Lulu Xue
Gan Zhao
Michael J. Mitchell
Research01 Oct 2024
Nature Nanotechnology

Volume: 20, P: 132-143
Phosphatase activity tunes two-component system sensor detection threshold

Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point mutations in sensor histidine kinase proteins.

Brian P. Landry
Rohan Palanki
Jeffrey J. Tabor
ResearchOpen Access12 Apr 2018
Nature Communications

Volume: 9, P: 1-10
Comment on: Premature delivery in the domestic sow in response to in utero delivery of AAV9 to fetal piglets

Apeksha Dave
Cara L. Berkowitz
William H. Peranteau
Comments & Opinion14 Mar 2023
Gene Therapy

Volume: 30, P: 232-235

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