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Showing 1–3 of 3 results
Advanced filters: Author: Rohit Chandwani Clear advanced filters

  • Post-translationally modified histones are recognized by effector proteins which contain specific binding modules; for example, the bromodomain-containing BET proteins bind acetylated lysine residues during gene activation. Here a synthetic small molecule is described that interferes with the binding of certain BET family members to acetylated histones. The compound inhibits activation of pro-inflammatory genes in macrophages and has activity in a mouse model of inflammatory disease.

    • Edwige Nicodeme
    • Kate L. Jeffrey
    • Alexander Tarakhovsky
    Research
    Nature
    Volume: 468, P: 1119-1123

  • In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.

    • Direna Alonso-Curbelo
    • Yu-Jui Ho
    • Scott W. Lowe
    Research
    Nature
    Volume: 590, P: 642-648

  • Restoring the function of p53 in a mouse model of pancreatic ductal adenocarcinoma leads to the accumulation of α-ketoglutarate, which increases levels of the 5-hydroxymethylcytosine chromatin modification and results in reduced tumour-cell fitness.

    • John P. Morris IV
    • Jossie J. Yashinskie
    • Scott W. Lowe
    Research
    Nature
    Volume: 573, P: 595-599