Nature Search

Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Aging-associated HELIOS deficiency in naive CD4⁺ T cells alters chromatin remodeling and promotes effector cell responses

Goronzy and colleagues examine differences in naive CD4⁺ T cells from young and older adults to TCR stimulation. They find reduced HELIOS expression in the elderly, resulting in increased CD25 expression and activation of pSTAT5 in FOXP3⁻ T cells. This scenario favors generation of short-lived effector T cells over memory cell populations.

Huimin Zhang
Rohit R. Jadhav
Jörg J. Goronzy
Research12 Dec 2022
Nature Immunology

Volume: 24, P: 96-109
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells

Homeostasis of memory T cells is modulated by each antigen encounter, thereby creating a heterogeneous population preventing precise tracking. Here, the authors use barcode-assisted tracing of Epstein-Barr virus-specific CD8⁺ memory T cells of young and older individuals to find antigen-guided, clonally divergent aging trajectories.

Ines Sturmlechner
Abhinav Jain
Jörg J. Goronzy
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-21
PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program

PD-1⁺TCF1⁺ stem-like CD8⁺ T cells—precursors of exhausted CD8⁺ T cells—are not fate-locked into the exhaustion program; their differentiation trajectory can be changed by IL-2 signals.

Masao Hashimoto
Koichi Araki
Rafi Ahmed
Research28 Sept 2022
Nature

Volume: 610, P: 173-181
Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

ORAI3 is part of pore forming calcium channels involved in T cell activation. Here the authors show that there is increased expression of ORAI3 in T cells from patients with rheumatoid arthritis and that the transcription factor IKAROS negatively regulates the ORAI3 promoter, indicating a regulatory loop that can control auto-reactivity of T cells in these patients.

Zhongde Ye
Yi Shen
Jörg J. Goronzy
ResearchOpen Access10 Feb 2021
Nature Communications

Volume: 12, P: 1-17
CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging

Chronic inflammation is a sign of immune system aging. Here the authors show that T cells from older adults contribute to inflammation due to CISH-mediated enhanced proteasomal degradation of a component of the proton pump V-ATPase, resulting in reduced lysosome function and the release of mtDNA and other amphisomal content.

Jun Jin
Yunmei Mu
Jorg J. Goronzy
Research17 Apr 2023
Nature Aging

Volume: 3, P: 600-616
Regulation of miR-181a expression in T cell aging

MicroRNA miR-181a has been implicated in the regulation of T cell activation and development. Here the authors show that miR-181a is regulated by a transcription factor, YY1, with reduced YY1 expression linked to reduced miR-181a in old individuals, while silencing YY1 impairs T cell functions largely through influencing the expression of miR-181a targets.

Zhongde Ye
Guangjin Li
Jörg J. Goronzy
ResearchOpen Access03 Aug 2018
Nature Communications

Volume: 9, P: 1-11
Induction of cancer stem cells from mouse fibroblasts

Snehal Shabrish
Leimarembi Devi Naorem
Indraneel Mittra
ResearchOpen Access15 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-wide DNA Methylation Analysis

Yao Wang
Rohit Ramakant Jadhav
Victor X. Jin
ResearchOpen Access29 Feb 2016
Scientific Reports

Volume: 6, P: 1-10

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