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Germline variants in cancer susceptibility genes among patients with mucosal melanoma

Afsaneh Amouzegar
Xiaogang Wu
P. Andrew Futreal
ResearchOpen Access23 May 2026
npj Genomic Medicine

P: 1-6
Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

Gavert et al. develop an organotypic platform to define individual-specific therapies, show that it can reflect in vivo PDX responses and find that combined MEK and Src inhibition is effective in a large panel of human colorectal tumors.

Nancy Gavert
Yaara Zwang
Ravid Straussman
Research10 Feb 2022
Nature Cancer

Volume: 3, P: 219-231

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Germline variants in cancer susceptibility genes among patients with mucosal melanoma

Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

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