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Showing 1–14 of 14 results
Advanced filters: Author: Roland Liblau Clear advanced filters

  • Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model, and associates with improved clinical score in 4 patients.

    • Catharina C. Gross
    • Céline Meyer
    • Roland Liblau
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells have now been found in people with narcolepsy.

    • Roland S. Liblau
    News & Views
    Nature
    Volume: 562, P: 46-48

  • Targeting the integrin VLA-4 with natalizumab has shown efficacy in treating multiple sclerosis, but relapse still occurs in some patients. Here the authors use a high-content cell imaging (HCI) pipeline and machine learning to assess the morphology of T cells from MS patients prior to natalizumab regime for defining features associated with treatment responses.

    • Beatriz Chaves
    • Juan Carlo Santos e Silva
    • Loïc Dupré
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • T-cell recognition of autoantigens is important in the development of autoimmune disease. Now, Hartmut Wekerle and his colleagues demonstrate that organ-specific autoimmune responses may be driven by T cells that simultaneously respond to two different autoantigens found within the same target tissue.

    • Gurumoorthy Krishnamoorthy
    • Amit Saxena
    • Hartmut Wekerle
    Research
    Nature Medicine
    Volume: 15, P: 626-632

  • Dysregulated cytokine networks are important in the pathogenesis of neuroinflammation. This Review discusses targeting cytokines and their receptors in non-infectious central nervous system inflammatory diseases such as multiple sclerosis and neurosarcoidosis, as well as in the neurotoxic adverse events that can be triggered by cancer immunotherapy.

    • Burkhard Becher
    • Tobias Derfuss
    • Roland Liblau
    Reviews
    Nature Reviews Drug Discovery
    Volume: 23, P: 862-879

  • The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer immunotherapy, but these agents carry a high risk of immune-related adverse events. Here, the authors introduce the mechanisms of action of ICIs and review their adverse effects on the CNS, which result in conditions such as paraneoplastic neurological syndromes and multiple sclerosis.

    • Lidia M. Yshii
    • Reinhard Hohlfeld
    • Roland S. Liblau
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 755-763

  • Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system are early hallmarks of multiple sclerosis. Here, the authors demonstrate that brain endothelial cells cross-present antigen to CD8+ T cells, thereby preventing their migration and initiating BBB breakdown.

    • Sidar Aydin
    • Javier Pareja
    • Britta Engelhardt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • T follicular regulatory cells control the magnitude of the germinal centre response. Here the authors show that these cells display specificity to self as well as foreign antigens, and can arise from Foxp3-negative precursors at early stages of immunization in a PD-L1 dependent manner.

    • Meryem Aloulou
    • Edward J. Carr
    • Michelle A. Linterman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Lymphatic endothelial cells (LECs) induce peripheral tolerance of CD8 T cells. Here the authors show that LECs cannot directly tolerize CD4 T cells as they lack the machinery for loading the antigenic peptide to MHC-II; instead, LECs pass these antigens to dendritic cells that induce CD4 tolerance.

    • Sherin J. Rouhani
    • Jacob D. Eccles
    • Victor H. Engelhard
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • This article reviews growing evidence suggesting that narcolepsy, a chronic sleep disorder caused by deficiency of hypocretin (also known as orexin), has an immune-mediated basis, explores the potential role of autoreactive lymphocytes in the disease process, and proposes future research directions to elucidate its pathogenesis.

    • Roland S. Liblau
    • Daniela Latorre
    • Emmanuel J. Mignot
    Reviews
    Nature Reviews Immunology
    Volume: 24, P: 33-48

  • The chemokine receptor CCR5 is thought to have a role in several CNS inflammatory diseases and infections. The role of CCR5 in HIV has already led to the development of effective and well-tolerated CCR5 antagonists, which could offer a readily available option for the treatment of CNS diseases. In this Review, Martin-Blondel et al. consider the evidence for a role of CCR5 in several CNS diseases and the rationale for use of CCR5 anatagonists in these conditions.

    • Guillaume Martin-Blondel
    • David Brassat
    • Roland S. Liblau
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 95-105

  • In this Review, Wiendl et al. consider how the study of rare but paradigmatic neuroimmunological diseases, including Susac syndrome, Rasmussen encephalitis and narcolepsy type 1, is providing fundamental insights into disease mechanisms that can be applied to more complex, heterogeneous neuroimmunological diseases such as multiple sclerosis.

    • Heinz Wiendl
    • Catharina C. Gross
    • Roland Liblau
    Reviews
    Nature Reviews Neurology
    Volume: 17, P: 433-447

  • In the past 20 years, understanding of the clinical manifestations, aetiopathophysiology, diagnosis and treatment of narcolepsy has greatly advanced. In this Review, Bassetti et al. present these advances, discuss unmet needs and offer future perspectives for the field of narcolepsy.

    • Claudio L. A. Bassetti
    • Antoine Adamantidis
    • Yves Dauvilliers
    Reviews
    Nature Reviews Neurology
    Volume: 15, P: 519-539