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Showing 1–2 of 2 results
Advanced filters: Author: Roland Steinacher Clear advanced filters

  • The PARylation activity of PARP recruits DNA repair proteins to damaged DNA, most likely via non-covalent protein-PAR interactions. Here, the authors show that PARP1 covalently PARylates base excision repair proteins to modulate their DNA transactions and thus promote active BER DNA demethylation.

    • Simon D. Schwarz
    • Jianming Xu
    • Roland Steinacher
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • TDG is a member of the uracil DNA glycosylase family of DNA repair enzymes. It has been implicated in gene regulation but its biological functions have been unclear. Here, a knockout of the Tdg gene in mice reveals functions in embryonic development and in the maintenance of chromatin states.

    • Daniel Cortázar
    • Christophe Kunz
    • Primo Schär
    Research
    Nature
    Volume: 470, P: 419-423