Although normal γδ T cell development depends on the E protein antagonist, Id3, Id3 deficiency produces different phenotypes in distinct γδ T cell subsets. Here, the authors demonstrate that Id3 deficiency impairs the development of Vγ3+ T cells, while promoting that of NKγδT cells expressing the invariant Vγ1Vδ6.3 TCR.
- Ariana Mihai
- Sang-Yun Lee
- David L. Wiest
