Mammalian livers are characterized by an alteration of chromosome numbers, or polyploidy. In this Review, Desdouets and collaborators describe the regulation of polyploidy in liver development and pathophysiology, and discuss the mechanisms of hepatocyte polyploidization and its role in liver tumorigenesis.
- Romain Donne
- Maëva Saroul-Aïnama
- Chantal Desdouets