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Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice

Here the authors report single-cell and spatial transcriptomics of young and aged male fibrotic mouse lungs. Age-related alterations in capillary sub-populations are associated with a proangiogenic phenotype linked to regeneration of the alveolar niche.

Marin Truchi
Marine Gautier-Isola
Bernard Mari
ResearchOpen Access06 Aug 2025
Nature Communications

Volume: 16, P: 1-21
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

In a post-approval study including more than 17,000 patients on the safety of pulsed field ablation, a new method for treatment of atrial fibrillation, the procedure was found to have a low rate of adverse events but was associated with some unexpected rare complications that will need further study.

Emmanuel Ekanem
Petr Neuzil
Vivek Y. Reddy
ResearchOpen Access08 Jul 2024
Nature Medicine

Volume: 30, P: 2020-2029
Imaging plant growth in 4D: robust tissue reconstruction and lineaging at cell resolution

A set of computational and imaging approaches, called MARS-ALT, permits three-dimensional tracking of plant tissue development, including cell lineaging, at cellular resolution. It is applied to the study of floral development in Arabidopsis.

Romain Fernandez
Pradeep Das
Christophe Godin
Research13 Jun 2010
Nature Methods

Volume: 7, P: 547-553
Vacuum levitation and motion control on chip

By combining fibre-based trapping and position detection with cold damping through planar electrodes, cooling of a silica nanoparticle particle motion to a few hundred phonons on a chip is achieved.

Bruno Melo
Marc T. Cuairan
Romain Quidant
ResearchOpen Access06 Jun 2024
Nature Nanotechnology

Volume: 19, P: 1270-1276
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

Epigenetic profiles can be predictive of macrophage transcriptional responses to influenza A virus infection in individuals of European and African ancestry. Ancestry-linked epigenetic differences appear to be genetically controlled.

Katherine A. Aracena
Yen-Lung Lin
Luis B. Barreiro
Research29 Feb 2024
Nature Genetics

Volume: 56, P: 408-419
Site- and allele-specific polycomb dysregulation in T-cell leukaemia

TAL1 is frequently deregulated in T-cell acute lymphoblastic leukaemias, but the mechanism remains largely unclear. Here the authors show that microinsertions upstream of TAL1 cause its epigenetic reactivation, and that the mode of TAL1activation correlates with prognosis.

Jean-Marc Navarro
Aurore Touzart
Bertrand Nadel
ResearchOpen Access23 Jan 2015
Nature Communications

Volume: 6, P: 1-11
The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4⁺CD8⁺ thymocytes

Michaël Mingueneau
Amandine Sansoni
Bernard Malissen
Research13 Apr 2008
Nature Immunology

Volume: 9, P: 522-532
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of T_H9 cells

T_H9 cells are associated with autoinflammatory diseases. Apetoh and colleagues demonstrate a molecular pathway which converts T_H9 cells into potent anticancer cells.

Frédérique Végran
Hélène Berger
Lionel Apetoh
Research29 Jun 2014
Nature Immunology

Volume: 15, P: 758-766
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

Audrey Burban
Ahmad Sharanek
Christiane Guguen-Guillouzo
ResearchOpen Access12 May 2017
Scientific Reports

Volume: 7, P: 1-17
Refining clinically relevant cut-offs of prostate specific antigen density for risk stratification in patients with PI-RADS 3 lesions

Georges Mjaess
Laura Haddad
Romain Diamand
Research24 Jul 2024
Prostate Cancer and Prostatic Diseases

Volume: 28, P: 173-179
Spatially localised expression of the glutamate decarboxylase gadB in Escherichia coli O157:H7 microcolonies in hydrogel matrices

Cédric Saint Martin
Nelly Caccia
Mickaël Desvaux
ResearchOpen Access14 Oct 2023
npj Science of Food

Volume: 7, P: 1-8
Integrative biology of T cell activation

TCR ligation activates multiple downstream pathways that lead to myriad functional outputs. Malissen and colleagues discuss how unbiased mass spectrometry using signaling hub 'bait' molecules, such as Lat, provides new insight into TCR signaling cascades.

Bernard Malissen
Claude Grégoire
Romain Roncagalli
Reviews19 Aug 2014
Nature Immunology

Volume: 15, P: 790-797
Slab melting boosts the mantle wedge contribution to Li-rich magmas

Erwin Schettino
Igór González-Pérez
Manuel E. Schilling
ResearchOpen Access02 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Black carbon aerosol number and mass concentration measurements by picosecond short-range elastic backscatter lidar

Romain Ceolato
Andrés E. Bedoya-Velásquez
Jérôme Yon
ResearchOpen Access19 May 2022
Scientific Reports

Volume: 12, P: 1-12
Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients

Claire Duflos
Kamila Solecki
François Roubille
ResearchOpen Access17 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Low fibrosis biomarker levels predict cardiac resynchronization therapy response

Grégoire Massoullié
Vincent Sapin
Romain Eschalier
ResearchOpen Access15 Apr 2019
Scientific Reports

Volume: 9, P: 1-9
Caveolin-1 rs4730751 single-nucleotide polymorphism may not influence kidney transplant allograft survival

Mehdi Maanaoui
Rémi Lenain
Christelle Cauffiez
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Spatial distribution of psychotic disorders in an urban area of France: an ecological study

Baptiste Pignon
Franck Schürhoff
Andrei Szöke
ResearchOpen Access18 May 2016
Scientific Reports

Volume: 6, P: 1-10
Efficient Synchronization of Dipolarly Coupled Vortex-Based Spin Transfer Nano-Oscillators

Nicolas Locatelli
Abbass Hamadeh
Grégoire de Loubens
ResearchOpen Access26 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

Gustavo J. Gozzi
Daniel Gonzalez
Carmen Garrido
Research08 May 2019
Cell Death & Differentiation

Volume: 27, P: 117-129
The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures

Romain Pacaud
Emeline Brocard
Pierre-François Cartron
ResearchOpen Access18 Mar 2014
Scientific Reports

Volume: 4, P: 1-9
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Diego Quattrone
Ulrich Reininghaus
Giuseppe D’Andrea
ResearchOpen Access10 Aug 2021
Translational Psychiatry

Volume: 11, P: 1-10

Search

Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Imaging plant growth in 4D: robust tissue reconstruction and lineaging at cell resolution

Vacuum levitation and motion control on chip

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

Site- and allele-specific polycomb dysregulation in T-cell leukaemia

The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4⁺CD8⁺ thymocytes

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of T_H9 cells

Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

Refining clinically relevant cut-offs of prostate specific antigen density for risk stratification in patients with PI-RADS 3 lesions

Spatially localised expression of the glutamate decarboxylase gadB in Escherichia coli O157:H7 microcolonies in hydrogel matrices

Integrative biology of T cell activation

Slab melting boosts the mantle wedge contribution to Li-rich magmas

Black carbon aerosol number and mass concentration measurements by picosecond short-range elastic backscatter lidar

Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients

Low fibrosis biomarker levels predict cardiac resynchronization therapy response

Caveolin-1 rs4730751 single-nucleotide polymorphism may not influence kidney transplant allograft survival

Spatial distribution of psychotic disorders in an urban area of France: an ecological study

Efficient Synchronization of Dipolarly Coupled Vortex-Based Spin Transfer Nano-Oscillators

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

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